CDC25B [The Human Chemical-Genetic Interaction Map Project]

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======= CDC25B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDC25B
  * **<color #00a2e8>Official Name</color>**: cell division cycle 25B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=994|994]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30305|P30305]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDC25B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDC25B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/116949|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008]. COMPLETENESS: complete on the 3' end. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rhodanese|
|M-inducer phosp|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of G2/MI transition of meiotic cell cycle|
|regulation of G2/MI transition of meiotic cell cycle|
|positive regulation of meiotic cell cycle phase transition|
|female meiosis I|
|regulation of meiotic cell cycle phase transition|
|oocyte maturation|
|positive regulation of meiotic cell cycle|
|positive regulation of G2/M transition of mitotic cell cycle|
|positive regulation of cell cycle G2/M phase transition|
|female meiotic nuclear division|
|oocyte development|
|positive regulation of cytokinesis|
|phosphoprotein phosphatase activity|
|oocyte differentiation|
|regulation of meiotic cell cycle|
|positive regulation of mitotic cell cycle phase transition|
|positive regulation of reproductive process|
|oogenesis|
|positive regulation of cell division|
|regulation of cytokinesis|
|positive regulation of cell cycle phase transition|
|protein tyrosine phosphatase activity|
|peptidyl-tyrosine dephosphorylation|
|meiosis I|
|meiosis I cell cycle process|
|spindle pole|
|female gamete generation|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|anatomical structure maturation|
|positive regulation of mitotic cell cycle|
|meiotic nuclear division|
|cell maturation|
|regulation of reproductive process|
|meiotic cell cycle process|
|regulation of cell division|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|protein dephosphorylation|
|meiotic cell cycle|
|developmental maturation|
|germ cell development|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|nuclear division|
|positive regulation of cell cycle process|
|dephosphorylation|
|organelle fission|
|cellular process involved in reproduction in multicellular organism|
|positive regulation of cell cycle|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|protein kinase binding|
|centrosome|
|cell division|
|positive regulation of protein kinase activity|
|positive regulation of kinase activity|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|positive regulation of transferase activity|
|developmental process involved in reproduction|
|mitotic cell cycle|
|gamete generation|
|regulation of cell cycle process|
|regulation of protein kinase activity|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|regulation of kinase activity|
|positive regulation of cell population proliferation|
|protein phosphorylation|
|regulation of transferase activity|
|multi-organism reproductive process|
|cell cycle process|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|regulation of cell cycle|
|positive regulation of protein modification process|
|phosphorylation|
|cell cycle|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|cell development|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-2.12|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.94|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|-1.92|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-1.85|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.77|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-1.71|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.71|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6006
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDC25B Expression in NALM6 Cells: 5.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>