CDC42 [The Human Chemical-Genetic Interaction Map Project]

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======= CDC42 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDC42
  * **<color #00a2e8>Official Name</color>**: cell division cycle 42
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=998|998]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P60953|P60953]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDC42&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDC42|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/116952|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups. {ECO:0000250|UniProtKB:P60766, ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:17038317, ECO:0000269|PubMed:26465210}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Miro|
|Arf|
|Ras|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|GBD domain binding|
|neuropilin signaling pathway|
|apolipoprotein A-I receptor binding|
|Cdc42 protein signal transduction|
|establishment of Golgi localization|
|thioesterase binding|
|regulation of attachment of spindle microtubules to kinetochore|
|positive regulation of pseudopodium assembly|
|viral RNA genome replication|
|Golgi transport complex|
|Golgi localization|
|regulation of pseudopodium assembly|
|modification of synaptic structure|
|establishment of epithelial cell apical/basal polarity|
|dendritic spine morphogenesis|
|polarized epithelial cell differentiation|
|positive regulation of actin cytoskeleton reorganization|
|positive regulation of lamellipodium assembly|
|establishment of apical/basal cell polarity|
|establishment of monopolar cell polarity|
|establishment or maintenance of monopolar cell polarity|
|macrophage differentiation|
|spindle midzone|
|viral genome replication|
|positive regulation of lamellipodium organization|
|dendritic spine development|
|regulation of lamellipodium assembly|
|positive regulation of filopodium assembly|
|dendritic spine organization|
|establishment of epithelial cell polarity|
|regulation of actin cytoskeleton reorganization|
|positive regulation of substrate adhesion-dependent cell spreading|
|positive regulation of cytokinesis|
|neuron projection organization|
|regulation of lamellipodium organization|
|morphogenesis of a polarized epithelium|
|substantia nigra development|
|regulation of filopodium assembly|
|establishment or maintenance of epithelial cell apical/basal polarity|
|interleukin-12-mediated signaling pathway|
|negative regulation of epidermal growth factor receptor signaling pathway|
|cellular response to interleukin-12|
|response to interleukin-12|
|establishment or maintenance of apical/basal cell polarity|
|establishment or maintenance of bipolar cell polarity|
|negative regulation of ERBB signaling pathway|
|positive regulation of stress fiber assembly|
|regulation of substrate adhesion-dependent cell spreading|
|T cell costimulation|
|lymphocyte costimulation|
|dendrite morphogenesis|
|positive regulation of actin filament bundle assembly|
|neural nucleus development|
|vascular endothelial growth factor receptor signaling pathway|
|cytoplasmic ribonucleoprotein granule|
|filopodium|
|mitotic spindle|
|Rho protein signal transduction|
|regulation of stress fiber assembly|
|organelle transport along microtubule|
|regulation of epidermal growth factor receptor signaling pathway|
|midbrain development|
|positive regulation of cell division|
|ephrin receptor signaling pathway|
|positive regulation of muscle cell differentiation|
|postsynapse organization|
|regulation of cytokinesis|
|regulation of actomyosin structure organization|
|regulation of ERBB signaling pathway|
|regulation of actin filament bundle assembly|
|integrin-mediated signaling pathway|
|Wnt signaling pathway, planar cell polarity pathway|
|cell projection|
|positive regulation of plasma membrane bounded cell projection assembly|
|regulation of chromosome segregation|
|dendrite development|
|regulation of establishment of planar polarity|
|myeloid leukocyte differentiation|
|establishment of cell polarity|
|positive regulation of cell-substrate adhesion|
|phagocytosis, engulfment|
|negative regulation of protein complex assembly|
|Golgi organization|
|non-canonical Wnt signaling pathway|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|cell cortex|
|Fc receptor mediated stimulatory signaling pathway|
|plasma membrane invagination|
|Fc-gamma receptor signaling pathway|
|membrane invagination|
|dendritic spine|
|regulation of cell shape|
|regulation of muscle cell differentiation|
|positive regulation of cell morphogenesis involved in differentiation|
|transport along microtubule|
|midbody|
|positive regulation of cell growth|
|regulation of cell division|
|cell junction assembly|
|cytoskeleton-dependent intracellular transport|
|regulation of morphogenesis of an epithelium|
|microtubule-based transport|
|establishment or maintenance of cell polarity|
|positive regulation of supramolecular fiber organization|
|regulation of plasma membrane bounded cell projection assembly|
|viral life cycle|
|regulation of cell projection assembly|
|positive regulation of T cell activation|
|regulation of cell-substrate adhesion|
|cell junction organization|
|positive regulation of leukocyte cell-cell adhesion|
|myeloid cell differentiation|
|positive regulation of cytoskeleton organization|
|ubiquitin protein ligase activity|
|actin filament organization|
|Fc receptor signaling pathway|
|Ras protein signal transduction|
|positive regulation of cell-cell adhesion|
|regulation of animal organ morphogenesis|
|positive regulation of growth|
|regulation of actin filament organization|
|synapse organization|
|microtubule-based movement|
|positive regulation of cell cycle process|
|blood coagulation|
|coagulation|
|regulation of leukocyte cell-cell adhesion|
|hemostasis|
|regulation of cell morphogenesis involved in differentiation|
|regulation of T cell activation|
|small GTPase mediated signal transduction|
|neuron projection|
|phagocytosis|
|GTPase activity|
|leukocyte differentiation|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|regulation of supramolecular fiber organization|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|positive regulation of lymphocyte activation|
|establishment of organelle localization|
|neuronal cell body|
|positive regulation of cell cycle|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|GTP binding|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|focal adhesion|
|regulation of cell growth|
|positive regulation of cell activation|
|endomembrane system organization|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|morphogenesis of an epithelium|
|cell morphogenesis involved in neuron differentiation|
|immune response-activating cell surface receptor signaling pathway|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|cell projection assembly|
|protein kinase binding|
|wound healing|
|neuron projection morphogenesis|
|immune response-regulating cell surface receptor signaling pathway|
|plasma membrane bounded cell projection morphogenesis|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|centrosome|
|actin cytoskeleton organization|
|regulation of body fluid levels|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of lymphocyte activation|
|cell part morphogenesis|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|endocytosis|
|hemopoiesis|
|cell morphogenesis involved in differentiation|
|immune response-activating signal transduction|
|tissue morphogenesis|
|actin filament-based process|
|response to wounding|
|organelle localization|
|protein-containing complex|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|Golgi membrane|
|positive regulation of organelle organization|
|activation of immune response|
|regulation of cell activation|
|immune system development|
|neuron projection development|
|regulation of growth|
|microtubule-based process|
|cytokine-mediated signaling pathway|
|import into cell|
|regulation of cell adhesion|
|epithelial cell differentiation|
|protein ubiquitination|
|regulation of plasma membrane bounded cell projection organization|
|viral process|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|brain development|
|regulation of cell cycle process|
|protein modification by small protein conjugation|
|head development|
|symbiotic process|
|neuron development|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|membrane organization|
|positive regulation of immune response|
|regulation of cell development|
|endoplasmic reticulum membrane|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|central nervous system development|
|protein modification by small protein conjugation or removal|
|cellular response to cytokine stimulus|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|immune effector process|
|response to cytokine|
|cytoskeleton organization|
|epithelium development|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|regulation of immune response|
|positive regulation of immune system process|
|cell projection organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|negative regulation of signal transduction|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|intracellular transport|
|generation of neurons|
|movement of cell or subcellular component|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|regulation of immune system process|
|intracellular signal transduction|
|tissue development|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.68|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.38|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.24|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.21|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.18|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-2.1|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.05|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-1.98|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.84|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-1.82|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.8|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.79|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.78|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.77|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.76|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.75|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.74|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-1.72|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|1.87|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mesdc1|MESDC1]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 486/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|17/28|
|blood|13/28|
|bone|19/26|
|breast|22/33|
|central nervous system|49/56|
|cervix|1/4|
|colorectal|5/17|
|esophagus|7/13|
|fibroblast|1/1|
|gastric|9/16|
|kidney|21/21|
|liver|15/20|
|lung|49/75|
|lymphocyte|8/16|
|ovary|22/26|
|pancreas|14/24|
|peripheral nervous system|11/16|
|plasma cell|10/15|
|prostate|0/1|
|skin|22/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|9/22|
|urinary tract|17/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8669
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDC42 Expression in NALM6 Cells: 7.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>