CDH11 [The Human Chemical-Genetic Interaction Map Project]

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======= CDH11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDH11
  * **<color #00a2e8>Official Name</color>**: cadherin 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1009|1009]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55287|P55287]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDH11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDH11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600023|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cadherin C|
|Cadherin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|corticospinal tract morphogenesis|
|central nervous system projection neuron axonogenesis|
|cell-cell adhesion mediated by cadherin|
|catenin complex|
|central nervous system neuron axonogenesis|
|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|
|cytoskeletal protein binding|
|central nervous system neuron development|
|Schaffer collateral - CA1 synapse|
|adherens junction organization|
|cell-cell junction assembly|
|cell-cell adherens junction|
|cell-cell junction organization|
|cell junction assembly|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|central nervous system neuron differentiation|
|cell junction organization|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|ossification|
|cadherin binding|
|glutamatergic synapse|
|axonogenesis|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|skeletal system development|
|cell-cell adhesion|
|cell part morphogenesis|
|cell morphogenesis involved in differentiation|
|cell surface|
|neuron projection development|
|calcium ion binding|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|protein homodimerization activity|
|cell adhesion|
|biological adhesion|
|central nervous system development|
|neuron differentiation|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|generation of neurons|
|neurogenesis|
|cell development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7971
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDH11 Expression in NALM6 Cells: 0.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>