CDH2 [The Human Chemical-Genetic Interaction Map Project]

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======= CDH2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDH2
  * **<color #00a2e8>Official Name</color>**: cadherin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1000|1000]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P19022|P19022]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDH2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDH2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/114020|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone. [provided by RefSeq, Nov 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cadherin C|
|Cadherin|
|Cadherin pro|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of postsynaptic density protein 95 clustering|
|neuroligin clustering involved in postsynaptic membrane assembly|
|positive regulation of synaptic vesicle clustering|
|regulation of oligodendrocyte progenitor proliferation|
|regulation of synaptic vesicle clustering|
|alpha-catenin binding|
|fascia adherens|
|postsynaptic membrane assembly|
|gamma-catenin binding|
|radial glial cell differentiation|
|regulation of postsynaptic membrane organization|
|integral component of presynaptic active zone membrane|
|regulation of postsynaptic density organization|
|postsynapse assembly|
|neuronal stem cell population maintenance|
|integral component of postsynaptic specialization membrane|
|cell-cell adhesion mediated by cadherin|
|catenin complex|
|postsynaptic membrane organization|
|plasma membrane raft|
|brain morphogenesis|
|membrane assembly|
|membrane biogenesis|
|neuroepithelial cell differentiation|
|intercalated disc|
|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|
|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|
|receptor clustering|
|cortical actin cytoskeleton|
|regulation of synaptic transmission, glutamatergic|
|apical part of cell|
|cytoskeletal protein binding|
|adherens junction organization|
|beta-catenin binding|
|localization within membrane|
|protein phosphatase binding|
|positive regulation of muscle cell differentiation|
|postsynapse organization|
|regulation of neural precursor cell proliferation|
|synapse assembly|
|columnar/cuboidal epithelial cell differentiation|
|regulation of postsynapse organization|
|sarcolemma|
|cell-cell junction assembly|
|cell-cell adherens junction|
|regulation of synaptic vesicle cycle|
|regulation of gliogenesis|
|cerebral cortex development|
|stem cell population maintenance|
|maintenance of cell number|
|cell-cell junction organization|
|regulation of muscle cell differentiation|
|cell junction assembly|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|glial cell differentiation|
|cell-cell junction|
|pallium development|
|negative regulation of canonical Wnt signaling pathway|
|lamellipodium|
|protein localization to plasma membrane|
|regulation of axonogenesis|
|regulation of protein localization to membrane|
|basolateral plasma membrane|
|homeostasis of number of cells|
|striated muscle cell differentiation|
|negative regulation of Wnt signaling pathway|
|cell junction organization|
|gliogenesis|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|protein localization to cell periphery|
|muscle cell differentiation|
|postsynaptic density|
|telencephalon development|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|synapse|
|synapse organization|
|regulation of canonical Wnt signaling pathway|
|regulation of cell morphogenesis involved in differentiation|
|endoplasmic reticulum lumen|
|cadherin binding|
|apical plasma membrane|
|neuron projection|
|regulation of Wnt signaling pathway|
|post-translational protein modification|
|collagen-containing extracellular matrix|
|forebrain development|
|blood vessel morphogenesis|
|focal adhesion|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|protein kinase binding|
|muscle structure development|
|protein localization to membrane|
|blood vessel development|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|cell-cell adhesion|
|vasculature development|
|cardiovascular system development|
|regulation of cellular protein localization|
|positive regulation of MAPK cascade|
|cell junction|
|regulation of vesicle-mediated transport|
|cell surface|
|tube morphogenesis|
|regulation of neuron differentiation|
|epithelial cell differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|calcium ion binding|
|cell morphogenesis|
|brain development|
|regulation of MAPK cascade|
|head development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|tube development|
|membrane organization|
|circulatory system development|
|protein homodimerization activity|
|regulation of cellular localization|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|central nervous system development|
|positive regulation of transport|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|epithelium development|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of organelle organization|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|generation of neurons|
|movement of cell or subcellular component|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|homeostatic process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 13/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|3/21|
|liver|2/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4169
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDH2 Expression in NALM6 Cells: -0.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>