CDK4 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= CDK4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDK4
  * **<color #00a2e8>Official Name</color>**: cyclin dependent kinase 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1019|1019]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P11802|P11802]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDK4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDK4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/123829|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. {ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:18827403, ECO:0000269|PubMed:9003781}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cyclin D2-CDK4 complex|
|cellular response to ionomycin|
|response to ionomycin|
|cellular response to phorbol 13-acetate 12-myristate|
|cellular response to ether|
|response to phorbol 13-acetate 12-myristate|
|positive regulation of cell size|
|response to ether|
|response to hyperoxia|
|negative regulation of cell cycle arrest|
|response to lead ion|
|positive regulation of G2/M transition of mitotic cell cycle|
|response to increased oxygen levels|
|cyclin-dependent protein serine/threonine kinase activity|
|cellular response to interleukin-4|
|cyclin-dependent protein kinase holoenzyme complex|
|positive regulation of cell cycle G2/M phase transition|
|cyclin binding|
|response to interleukin-4|
|cyclin-dependent protein serine/threonine kinase regulator activity|
|adipose tissue development|
|response to testosterone|
|positive regulation of fibroblast proliferation|
|regulation of lipid catabolic process|
|cellular response to fatty acid|
|regulation of insulin receptor signaling pathway|
|regulation of multicellular organism growth|
|regulation of cellular response to insulin stimulus|
|animal organ regeneration|
|lens development in camera-type eye|
|positive regulation of mitotic cell cycle phase transition|
|regulation of fibroblast proliferation|
|cellular response to alcohol|
|response to fatty acid|
|cellular response to ketone|
|positive regulation of cell cycle phase transition|
|response to antineoplastic agent|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of cyclin-dependent protein kinase activity|
|negative regulation of G1/S transition of mitotic cell cycle|
|negative regulation of cell cycle G1/S phase transition|
|regulation of cell cycle arrest|
|chromatin|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|bicellular tight junction|
|positive regulation of translation|
|circadian rhythm|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of cellular amide metabolic process|
|positive regulation of mitotic cell cycle|
|regeneration|
|cellular response to insulin stimulus|
|regulation of cell cycle G1/S phase transition|
|transcription initiation from RNA polymerase II promoter|
|regulation of cell size|
|cellular response to lipopolysaccharide|
|regulation of lipid biosynthetic process|
|cellular response to molecule of bacterial origin|
|response to ketone|
|regulation of G2/M transition of mitotic cell cycle|
|transcription factor complex|
|cellular response to acid chemical|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|cellular response to biotic stimulus|
|DNA-templated transcription, initiation|
|connective tissue development|
|response to insulin|
|negative regulation of cell cycle phase transition|
|response to alcohol|
|nuclear membrane|
|cellular response to peptide hormone stimulus|
|protein-containing complex binding|
|mitotic cell cycle phase transition|
|rhythmic process|
|cell cycle phase transition|
|positive regulation of cell cycle process|
|negative regulation of mitotic cell cycle|
|camera-type eye development|
|response to lipopolysaccharide|
|negative regulation of cell cycle process|
|response to molecule of bacterial origin|
|cellular response to peptide|
|regulation of developmental growth|
|response to acid chemical|
|regulation of translation|
|eye development|
|visual system development|
|sensory system development|
|response to metal ion|
|positive regulation of cell cycle|
|regulation of cellular component size|
|response to oxygen levels|
|response to peptide hormone|
|regulation of lipid metabolic process|
|cellular response to drug|
|regulation of cellular amide metabolic process|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|response to peptide|
|transcription by RNA polymerase II|
|cell division|
|response to toxic substance|
|regulation of anatomical structure size|
|regulation of protein serine/threonine kinase activity|
|cellular response to lipid|
|posttranscriptional regulation of gene expression|
|response to inorganic substance|
|cellular response to organic cyclic compound|
|sensory organ development|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|regulation of mitotic cell cycle|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|RNA biosynthetic process|
|cellular response to nitrogen compound|
|regulation of growth|
|mitotic cell cycle|
|response to bacterium|
|positive regulation of cell death|
|perinuclear region of cytoplasm|
|regulation of cell cycle process|
|regulation of protein kinase activity|
|response to lipid|
|nucleolus|
|regulation of kinase activity|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of catabolic process|
|cell cycle process|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|response to drug|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|phosphorylation|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|response to biotic stimulus|
|cell cycle|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|ATP binding|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.617|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 115/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|1/28|
|bone|11/26|
|breast|13/33|
|central nervous system|5/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|2/21|
|liver|5/20|
|lung|11/75|
|lymphocyte|2/16|
|ovary|3/26|
|pancreas|2/24|
|peripheral nervous system|2/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|5/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17658
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDK4 Expression in NALM6 Cells: 7.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>