CDSN [The Human Chemical-Genetic Interaction Map Project]

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======= CDSN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDSN
  * **<color #00a2e8>Official Name</color>**: corneodesmosin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1041|1041]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15517|Q15517]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDSN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDSN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602593|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein found in corneodesmosomes, which localize to human epidermis and other cornified squamous epithelia. The encoded protein undergoes a series of cleavages during corneocyte maturation. This gene is highly polymorphic in human populations, and variation has been associated with skin diseases such as psoriasis, hypotrichosis and peeling skin syndrome. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6. [provided by RefSeq, Dec 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|corneocyte desquamation|
|regulation of cornification|
|negative regulation of cornification|
|corneocyte development|
|delamination|
|negative regulation of keratinocyte differentiation|
|skin morphogenesis|
|keratinocyte development|
|negative regulation of epidermal cell differentiation|
|negative regulation of epidermis development|
|desmosome|
|negative regulation of epithelial cell differentiation|
|regulation of keratinocyte differentiation|
|regulation of epidermal cell differentiation|
|cornified envelope|
|regulation of epidermis development|
|cornification|
|regulation of epithelial cell differentiation|
|cell-cell junction|
|negative regulation of cell-cell adhesion|
|epithelial cell development|
|keratinization|
|negative regulation of cell adhesion|
|keratinocyte differentiation|
|epidermal cell differentiation|
|skin development|
|regulation of cell-cell adhesion|
|epidermis development|
|cell-cell adhesion|
|epithelial cell differentiation|
|regulation of cell adhesion|
|negative regulation of cell differentiation|
|protein homodimerization activity|
|negative regulation of programmed cell death|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|animal organ morphogenesis|
|negative regulation of cell death|
|programmed cell death|
|cell death|
|epithelium development|
|negative regulation of multicellular organismal process|
|regulation of programmed cell death|
|cell development|
|regulation of cell death|
|tissue development|
|regulation of cell differentiation|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-2.32|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11768
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDSN Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>