CEACAM5 [The Human Chemical-Genetic Interaction Map Project]

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======= CEACAM5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CEACAM5
  * **<color #00a2e8>Official Name</color>**: CEA cell adhesion molecule 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1048|1048]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P06731|P06731]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CEACAM5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CEACAM5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/114890|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins. {ECO:0000269|PubMed:10864933}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|V-set|
|ig|
|I-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|integral component of external side of plasma membrane|
|GPI anchor binding|
|negative regulation of anoikis|
|negative regulation of myotube differentiation|
|regulation of anoikis|
|negative regulation of striated muscle cell differentiation|
|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|
|negative regulation of muscle cell differentiation|
|regulation of myotube differentiation|
|homotypic cell-cell adhesion|
|anchored component of membrane|
|regulation of striated muscle cell differentiation|
|regulation of muscle cell differentiation|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|basolateral plasma membrane|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|apical plasma membrane|
|leukocyte migration|
|cell-cell adhesion|
|cell surface|
|negative regulation of cell differentiation|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|cell migration|
|negative regulation of cell death|
|programmed cell death|
|identical protein binding|
|cell motility|
|localization of cell|
|cell death|
|locomotion|
|integral component of plasma membrane|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of cell death|
|regulation of cell differentiation|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5138
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CEACAM5 Expression in NALM6 Cells: 1.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>