CENPF [The Human Chemical-Genetic Interaction Map Project]

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======= CENPF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CENPF
  * **<color #00a2e8>Official Name</color>**: centromere protein F
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1063|1063]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49454|P49454]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CENPF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CENPF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600236|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity against chlamydia. {ECO:0000269|PubMed:12974617, ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:7542657, ECO:0000269|PubMed:7651420}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cenp-F N|
|Cenp-F leu zip|
|Rb-bdg C Cenp-F|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pronucleus|
|ciliary transition fiber|
|condensed chromosome outer kinetochore|
|kinetochore assembly|
|kinetochore organization|
|dynein complex binding|
|spindle checkpoint|
|mitotic spindle assembly checkpoint|
|mitotic spindle checkpoint|
|spindle assembly checkpoint|
|negative regulation of mitotic metaphase/anaphase transition|
|negative regulation of metaphase/anaphase transition of cell cycle|
|ventricular system development|
|negative regulation of mitotic sister chromatid separation|
|negative regulation of chromosome separation|
|negative regulation of mitotic sister chromatid segregation|
|negative regulation of sister chromatid segregation|
|negative regulation of chromosome segregation|
|centromere complex assembly|
|negative regulation of mitotic nuclear division|
|negative regulation of nuclear division|
|regulation of mitotic metaphase/anaphase transition|
|regulation of metaphase/anaphase transition of cell cycle|
|chromosome, centromeric region|
|metaphase plate congression|
|regulation of mitotic sister chromatid separation|
|regulation of chromosome separation|
|regulation of mitotic sister chromatid segregation|
|establishment of chromosome localization|
|chromosome localization|
|regulation of sister chromatid segregation|
|kinetochore|
|regulation of chromosome segregation|
|axoneme|
|nuclear matrix|
|DNA biosynthetic process|
|chromatin|
|spindle|
|spindle pole|
|regulation of striated muscle tissue development|
|negative regulation of chromosome organization|
|regulation of muscle tissue development|
|ciliary basal body|
|regulation of muscle organ development|
|mitotic cell cycle checkpoint|
|midbody|
|regulation of mitotic nuclear division|
|nuclear envelope|
|protein C-terminus binding|
|regulation of nuclear division|
|cell cycle checkpoint|
|regulation of G2/M transition of mitotic cell cycle|
|protein-DNA complex assembly|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|nuclear chromosome segregation|
|negative regulation of cell cycle phase transition|
|protein-DNA complex subunit organization|
|kidney development|
|chromosome segregation|
|renal system development|
|muscle organ development|
|negative regulation of mitotic cell cycle|
|urogenital system development|
|negative regulation of cell cycle process|
|transcription factor binding|
|regulation of chromosome organization|
|establishment of organelle localization|
|negative regulation of organelle organization|
|chromatin binding|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|muscle structure development|
|centrosome|
|cell division|
|cell population proliferation|
|negative regulation of cell cycle|
|organelle localization|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|perinuclear region of cytoplasm|
|negative regulation of cellular component organization|
|brain development|
|DNA metabolic process|
|regulation of cell cycle process|
|organelle assembly|
|head development|
|cellular protein-containing complex assembly|
|protein homodimerization activity|
|central nervous system development|
|cell cycle process|
|response to drug|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|protein transport|
|negative regulation of cellular biosynthetic process|
|peptide transport|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|amide transport|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.65|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-2.15|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-1.94|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.86|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11909
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CENPF Expression in NALM6 Cells: 9.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>