CETN1 [The Human Chemical-Genetic Interaction Map Project]

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======= CETN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CETN1
  * **<color #00a2e8>Official Name</color>**: centrin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1068|1068]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12798|Q12798]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CETN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CETN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603187|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a fundamental role in microtubule-organizing center structure and function.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|efhand|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|heterotrimeric G-protein binding|
|centriole replication|
|G-protein beta/gamma-subunit complex binding|
|centriole assembly|
|centrosome duplication|
|photoreceptor connecting cilium|
|cellular response to heat|
|centrosome cycle|
|microtubule organizing center organization|
|response to heat|
|nucleotide-excision repair|
|spindle pole|
|centriole|
|response to temperature stimulus|
|microtubule binding|
|microtubule cytoskeleton organization|
|centrosome|
|cell division|
|DNA repair|
|microtubule-based process|
|mitotic cell cycle|
|calcium ion binding|
|DNA metabolic process|
|organelle assembly|
|cellular response to DNA damage stimulus|
|cell cycle process|
|cytoskeleton organization|
|response to abiotic stimulus|
|cell cycle|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|-2.41|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-2.28|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.05|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-1.88|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-1.82|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.73|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|1.79|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.87|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.92|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|1.93|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|1.96|
|[[:results:exp302|35°C R06 exp302]]|2.03|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|2.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7426
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CETN1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>