CHKA [The Human Chemical-Genetic Interaction Map Project]

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======= CHKA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHKA
  * **<color #00a2e8>Official Name</color>**: choline kinase alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1119|1119]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35790|P35790]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHKA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHKA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/118491|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline. {ECO:0000269|PubMed:19915674}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Choline kinase|
|APH|
|DUF227|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to polycyclic arene|
|response to 3-methylcholanthrene|
|ethanolamine metabolic process|
|choline kinase activity|
|cholinesterase activity|
|ethanolamine kinase activity|
|choline binding|
|CDP-choline pathway|
|ethanolamine-containing compound metabolic process|
|choline metabolic process|
|primary amino compound metabolic process|
|phosphatidylethanolamine biosynthetic process|
|phosphatidylethanolamine metabolic process|
|phosphatidylcholine biosynthetic process|
|cellular biogenic amine metabolic process|
|drug binding|
|cellular amine metabolic process|
|amine metabolic process|
|phosphatidylcholine metabolic process|
|primary alcohol metabolic process|
|neurotransmitter metabolic process|
|ammonium ion metabolic process|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|lipid transport|
|glycerophospholipid metabolic process|
|alcohol metabolic process|
|lipid localization|
|regulation of neurotransmitter levels|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|organic hydroxy compound metabolic process|
|response to toxic substance|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|protein homodimerization activity|
|organophosphate metabolic process|
|response to organic cyclic compound|
|cellular lipid metabolic process|
|response to drug|
|lipid metabolic process|
|phosphorylation|
|organonitrogen compound biosynthetic process|
|ATP binding|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-4.38|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-4.33|
|[[:results:exp358|FK-506 5μM R07 exp358]]|-3.79|
|[[:results:exp169|BH1 1μM R04 exp169]]|-3.74|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-3.72|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-3.57|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-3.49|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-3.41|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-3.4|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-3.32|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-3.24|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-3.04|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-3|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-3|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-2.93|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-2.81|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-2.77|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-2.75|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-2.64|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|-2.62|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-2.6|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-2.54|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-2.51|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-2.49|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-2.47|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.42|
|[[:results:exp114|A-196 10μM R03 exp114]]|-2.36|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-2.36|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-2.33|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.32|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-2.22|
|[[:results:exp149|SB203580 25μM R03 exp149]]|-2.18|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-2.14|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|-2.09|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-2.07|
|[[:results:exp453|B02 10μM R08 exp453]]|-2.04|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-2.04|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-2.03|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|-1.98|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|-1.94|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-1.93|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|-1.86|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.86|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-1.8|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-1.77|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-1.77|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.77|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.73|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.72|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.74|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.77|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.79|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.9|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|2.03|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.09|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|2.11|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.16|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.49|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:flvcr1|FLVCR1]]|0.74|
|[[:human genes:v:vkorc1l1|VKORC1L1]]|0.594|
|[[:human genes:c:cept1|CEPT1]]|0.569|
|[[:human genes:m:mbtps1|MBTPS1]]|0.558|
|[[:human genes:p:pcyt1a|PCYT1A]]|0.531|
|[[:human genes:a:arpc4|ARPC4]]|0.504|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.502|
|[[:human genes:g:gpr107|GPR107]]|0.491|
|[[:human genes:a:arpc2|ARPC2]]|0.482|
|[[:human genes:c:cog5|COG5]]|0.477|
|[[:human genes:s:sptlc1|SPTLC1]]|0.471|
|[[:human genes:m:mbtps2|MBTPS2]]|0.469|
|[[:human genes:s:sptlc2|SPTLC2]]|0.467|
|[[:human genes:m:mmd|MMD]]|0.467|
|[[:human genes:g:gpr89a|GPR89A]]|0.466|
|[[:human genes:a:actr2|ACTR2]]|0.459|
|[[:human genes:k:kdsr|KDSR]]|0.448|
|[[:human genes:s:sptssa|SPTSSA]]|0.438|
|[[:human genes:g:gpr89b|GPR89B]]|0.436|
|[[:human genes:a:arl1|ARL1]]|0.431|
|[[:human genes:c:cog7|COG7]]|0.429|
|[[:human genes:u:uso1|USO1]]|0.429|
|[[:human genes:h:htt|HTT]]|0.428|
|[[:human genes:s:scap|SCAP]]|0.427|
|[[:human genes:c:commd5|COMMD5]]|0.426|
|[[:human genes:l:lsmd1|LSMD1]]|0.426|
|[[:human genes:c:cnep1r1|CNEP1R1]]|0.421|
|[[:human genes:r:rgp1|RGP1]]|0.421|
|[[:human genes:s:slc5a3|SLC5A3]]|0.417|
|[[:human genes:d:dolk|DOLK]]|0.416|
|[[:human genes:d:dmxl1|DMXL1]]|0.411|
|[[:human genes:d:dpm3|DPM3]]|0.409|
|[[:human genes:u:unc50|UNC50]]|0.408|
|[[:human genes:u:ube2g2|UBE2G2]]|0.406|
|[[:human genes:a:atp2a2|ATP2A2]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 10/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11902
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHKA Expression in NALM6 Cells: 5.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>