CHORDC1 [The Human Chemical-Genetic Interaction Map Project]

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======= CHORDC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHORDC1
  * **<color #00a2e8>Official Name</color>**: cysteine and histidine rich domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26973|26973]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UHD1|Q9UHD1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHORDC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHORDC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604353|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis. {ECO:0000269|PubMed:20230755}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CS|
|CHORD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of Rho-dependent protein serine/threonine kinase activity|
|regulation of Rho-dependent protein serine/threonine kinase activity|
|ADP binding|
|Hsp90 protein binding|
|regulation of centrosome duplication|
|chaperone-mediated protein folding|
|regulation of centrosome cycle|
|regulation of cellular response to heat|
|negative regulation of protein serine/threonine kinase activity|
|regulation of microtubule cytoskeleton organization|
|regulation of microtubule-based process|
|negative regulation of protein kinase activity|
|protein folding|
|negative regulation of kinase activity|
|negative regulation of transferase activity|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|cellular component|
|regulation of protein serine/threonine kinase activity|
|regulation of cytoskeleton organization|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|regulation of cellular response to stress|
|regulation of cell cycle process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|zinc ion binding|
|regulation of kinase activity|
|regulation of transferase activity|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of cell cycle|
|regulation of organelle organization|
|regulation of protein phosphorylation|
|regulation of response to stress|
|ATP binding|
|regulation of phosphorylation|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.81|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.467|
|[[:human genes:h:hars|HARS]]|0.452|
|[[:human genes:u:uap1|UAP1]]|0.451|
|[[:human genes:g:gfpt1|GFPT1]]|0.434|
|[[:human genes:r:rnmt|RNMT]]|0.42|
|[[:human genes:d:dhps|DHPS]]|0.412|
|[[:human genes:r:rptor|RPTOR]]|0.411|
|[[:human genes:g:gmppb|GMPPB]]|0.41|
|[[:human genes:o:oraov1|ORAOV1]]|0.409|
|[[:human genes:t:triap1|TRIAP1]]|0.409|
|[[:human genes:t:tgs1|TGS1]]|0.407|
|[[:human genes:p:pmm2|PMM2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 460/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|17/28|
|blood|19/28|
|bone|16/26|
|breast|21/33|
|central nervous system|32/56|
|cervix|3/4|
|colorectal|11/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|10/16|
|kidney|8/21|
|liver|14/20|
|lung|46/75|
|lymphocyte|10/16|
|ovary|11/26|
|pancreas|19/24|
|peripheral nervous system|8/16|
|plasma cell|9/15|
|prostate|0/1|
|skin|13/24|
|soft tissue|4/9|
|thyroid|1/2|
|upper aerodigestive|16/22|
|urinary tract|25/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1472
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.07 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHORDC1 Expression in NALM6 Cells: 7.07'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>