CHRNA1 [The Human Chemical-Genetic Interaction Map Project]

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======= CHRNA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHRNA1
  * **<color #00a2e8>Official Name</color>**: cholinergic receptor nicotinic alpha 1 subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1134|1134]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P02708|P02708]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHRNA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHRNA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/100690|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The muscle acetylcholine receptor consiststs of 5 subunits of 4 different types: 2 alpha subunits and 1 each of the beta, gamma, and delta subunits. This gene encodes an alpha subunit that plays a role in acetlycholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Nov 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. {ECO:0000269|PubMed:27375219}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Neur chan memb|
|Neur chan LBD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|skeletal muscle tissue growth|
|acetylcholine receptor activity|
|acetylcholine-gated cation-selective channel activity|
|acetylcholine binding|
|acetylcholine-gated channel complex|
|muscle cell cellular homeostasis|
|ion channel activity|
|integral component of postsynaptic specialization membrane|
|synaptic transmission, cholinergic|
|neuronal action potential|
|skeletal muscle contraction|
|neuromuscular synaptic transmission|
|neuron cellular homeostasis|
|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential|
|neuromuscular junction development|
|multicellular organismal movement|
|musculoskeletal movement|
|extracellular ligand-gated ion channel activity|
|response to nicotine|
|transmission of nerve impulse|
|excitatory postsynaptic potential|
|chemical synaptic transmission, postsynaptic|
|neuromuscular junction|
|action potential|
|regulation of postsynaptic membrane potential|
|neuromuscular process|
|striated muscle contraction|
|skeletal muscle tissue development|
|skeletal muscle organ development|
|multicellular organismal signaling|
|postsynaptic membrane|
|muscle contraction|
|synapse|
|synapse organization|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|muscle system process|
|neuron projection|
|anatomical structure homeostasis|
|developmental growth|
|growth|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|trans-synaptic signaling|
|synaptic signaling|
|muscle structure development|
|response to toxic substance|
|cell junction|
|cell surface|
|cation transport|
|cellular homeostasis|
|ion transmembrane transport|
|response to drug|
|cell-cell signaling|
|transmembrane transport|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|homeostatic process|
|tissue development|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.481|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7549
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHRNA1 Expression in NALM6 Cells: 3.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>