CHRNA7 [The Human Chemical-Genetic Interaction Map Project]

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======= CHRNA7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHRNA7
  * **<color #00a2e8>Official Name</color>**: cholinergic receptor nicotinic alpha 7 subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1139|1139]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P36544|P36544]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHRNA7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHRNA7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/118511|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012].  Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. 
  * **<color #00a2e8>UniProt Summary</color>**:  After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Neur chan LBD|
|Neur chan memb|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of CoA-transferase activity|
|positive regulation of CoA-transferase activity|
|sensory processing|
|dendrite arborization|
|chloride channel regulator activity|
|regulation of amyloid fibril formation|
|short-term memory|
|toxic substance binding|
|neuron projection arborization|
|negative regulation of amyloid-beta formation|
|negative regulation of amyloid precursor protein catabolic process|
|positive regulation of amyloid-beta formation|
|acetylcholine-gated cation-selective channel activity|
|acetylcholine receptor activity|
|acetylcholine-gated channel complex|
|acetylcholine binding|
|positive regulation of amyloid precursor protein catabolic process|
|positive regulation of long-term synaptic potentiation|
|ion channel activity|
|synaptic transmission, cholinergic|
|regulation of amyloid-beta formation|
|positive regulation of excitatory postsynaptic potential|
|acetylcholine receptor signaling pathway|
|plasma membrane raft|
|dendritic spine organization|
|response to acetylcholine|
|cellular response to acetylcholine|
|regulation of amyloid precursor protein catabolic process|
|postsynaptic signal transduction|
|modulation of excitatory postsynaptic potential|
|neuron projection organization|
|regulation of long-term synaptic potentiation|
|extracellular ligand-gated ion channel activity|
|response to nicotine|
|response to amyloid-beta|
|calcium channel activity|
|dendrite morphogenesis|
|negative regulation of tumor necrosis factor production|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of nervous system process|
|excitatory postsynaptic potential|
|chemical synaptic transmission, postsynaptic|
|amyloid-beta binding|
|postsynapse|
|postsynapse organization|
|signal transduction involved in cellular response to ammonium ion|
|regulation of postsynaptic membrane potential|
|dendrite development|
|memory|
|cellular response to ammonium ion|
|regulation of nervous system process|
|transmembrane signaling receptor activity|
|negative regulation of cellular amide metabolic process|
|regulation of tumor necrosis factor production|
|positive regulation of synaptic transmission|
|positive regulation of cellular amide metabolic process|
|regulation of tumor necrosis factor superfamily cytokine production|
|activation of MAPK activity|
|positive regulation of angiogenesis|
|positive regulation of vasculature development|
|response to ammonium ion|
|regulation of synaptic plasticity|
|calcium ion transmembrane transport|
|postsynaptic membrane|
|positive regulation of ERK1 and ERK2 cascade|
|calcium ion transport|
|learning or memory|
|positive regulation of MAP kinase activity|
|synapse|
|synapse organization|
|negative regulation of cytokine production|
|regulation of angiogenesis|
|regulation of ERK1 and ERK2 cascade|
|divalent metal ion transport|
|cognition|
|divalent inorganic cation transport|
|regulation of neuron death|
|neuron projection|
|regulation of vasculature development|
|activation of protein kinase activity|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|response to hypoxia|
|regulation of supramolecular fiber organization|
|response to decreased oxygen levels|
|response to oxygen levels|
|regulation of cellular amide metabolic process|
|cellular response to drug|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|cell morphogenesis involved in neuron differentiation|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|synaptic signaling|
|cellular divalent inorganic cation homeostasis|
|response to peptide|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|divalent inorganic cation homeostasis|
|response to toxic substance|
|cell part morphogenesis|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|cell junction|
|cell morphogenesis involved in differentiation|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|behavior|
|positive regulation of kinase activity|
|regulation of system process|
|cellular response to hormone stimulus|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|neuron projection development|
|regulation of cytokine production|
|cation homeostasis|
|inorganic ion homeostasis|
|cell morphogenesis|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|ion homeostasis|
|regulation of protein kinase activity|
|neuron development|
|cellular component morphogenesis|
|cation transport|
|regulation of kinase activity|
|protein homodimerization activity|
|cellular homeostasis|
|response to hormone|
|positive regulation of cell population proliferation|
|ion transmembrane transport|
|sensory perception|
|regulation of transferase activity|
|response to organonitrogen compound|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cell projection organization|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|transmembrane transport|
|positive regulation of developmental process|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|generation of neurons|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5350
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHRNA7 Expression in NALM6 Cells: 2.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>