CHTF8 [The Human Chemical-Genetic Interaction Map Project]

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======= CHTF8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHTF8
  * **<color #00a2e8>Official Name</color>**: chromosome transmission fidelity factor 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54921|54921]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P0CG13|P0CG13]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHTF8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHTF8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613202|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single- stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates POLH, which is suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with replication fork progression. {ECO:0000269|PubMed:12930902, ECO:0000269|PubMed:17545166}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ctf8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of DNA-directed DNA polymerase activity|
|positive regulation of DNA-directed DNA polymerase activity|
|Ctf18 RFC-like complex|
|DNA clamp loader activity|
|mitotic sister chromatid cohesion|
|single-stranded DNA helicase activity|
|sister chromatid cohesion|
|regulation of DNA-dependent DNA replication|
|positive regulation of DNA biosynthetic process|
|mitotic sister chromatid segregation|
|regulation of DNA replication|
|DNA duplex unwinding|
|regulation of DNA biosynthetic process|
|DNA geometric change|
|sister chromatid segregation|
|mitotic nuclear division|
|positive regulation of DNA metabolic process|
|DNA replication|
|nuclear chromosome segregation|
|chromosome segregation|
|nuclear division|
|DNA conformation change|
|organelle fission|
|regulation of DNA metabolic process|
|mitotic cell cycle process|
|positive regulation of transferase activity|
|mitotic cell cycle|
|regulation of transferase activity|
|cell cycle process|
|chromosome organization|
|cell cycle|
|positive regulation of catalytic activity|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.22|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.08|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-2.05|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.74|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.73|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dscc1|DSCC1]]|0.705|
|[[:human genes:c:chtf18|CHTF18]]|0.564|
|[[:human genes:x:xrcc1|XRCC1]]|0.454|
|[[:human genes:p:pole4|POLE4]]|0.424|
|[[:human genes:m:mcm9|MCM9]]|0.415|
|[[:human genes:p:pole3|POLE3]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 85/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|0/28|
|bone|5/26|
|breast|7/33|
|central nervous system|10/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|1/13|
|fibroblast|1/1|
|gastric|5/16|
|kidney|5/21|
|liver|0/20|
|lung|9/75|
|lymphocyte|0/16|
|ovary|4/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|4/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1213
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHTF8 Expression in NALM6 Cells: 6.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>