CLDN4 [The Human Chemical-Genetic Interaction Map Project]

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======= CLDN4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CLDN4
  * **<color #00a2e8>Official Name</color>**: claudin 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1364|1364]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14493|O14493]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CLDN4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CLDN4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602909|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250|UniProtKB:O35054}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PMP22 Claudin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|renal absorption|
|apicolateral plasma membrane|
|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|
|establishment of skin barrier|
|regulation of water loss via skin|
|basal plasma membrane|
|response to progesterone|
|chloride channel complex|
|chloride channel activity|
|lateral plasma membrane|
|multicellular organismal water homeostasis|
|water homeostasis|
|chloride transmembrane transport|
|chloride transport|
|inorganic anion transmembrane transport|
|renal system process|
|bicellular tight junction|
|transmembrane signaling receptor activity|
|circadian rhythm|
|inorganic anion transport|
|female pregnancy|
|structural molecule activity|
|response to ketone|
|multi-multicellular organism process|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|anion transmembrane transport|
|rhythmic process|
|apical plasma membrane|
|multicellular organismal homeostasis|
|response to steroid hormone|
|skin development|
|regulation of body fluid levels|
|cell-cell adhesion|
|anion transport|
|inorganic ion transmembrane transport|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|cell adhesion|
|biological adhesion|
|ion transmembrane transport|
|multi-organism reproductive process|
|response to drug|
|identical protein binding|
|chemical homeostasis|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|homeostatic process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5726
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CLDN4 Expression in NALM6 Cells: 1.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>