CLEC4M [The Human Chemical-Genetic Interaction Map Project]

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======= CLEC4M =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CLEC4M
  * **<color #00a2e8>Official Name</color>**: C-type lectin domain family 4 member M
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10332|10332]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H2X3|Q9H2X3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CLEC4M&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CLEC4M|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605872|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lectin C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peptide antigen transport|
|ICAM-3 receptor activity|
|virion attachment to host cell|
|adhesion of symbiont to host cell|
|virion binding|
|adhesion of symbiont to host|
|mannose binding|
|viral genome replication|
|modulation by virus of host morphology or physiology|
|peptide antigen binding|
|modification by symbiont of host morphology or physiology|
|leukocyte cell-cell adhesion|
|intracellular transport of virus|
|host cell|
|transport of virus|
|calcium-dependent protein binding|
|cell-cell recognition|
|multi-organism localization|
|multi-organism transport|
|virus receptor activity|
|viral entry into host cell|
|entry into host|
|entry into host cell|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|modification of morphology or physiology of other organism|
|interaction with host|
|carbohydrate binding|
|antigen processing and presentation of peptide antigen|
|viral life cycle|
|signaling receptor activity|
|antigen processing and presentation|
|cell recognition|
|cell-cell adhesion|
|endocytosis|
|adaptive immune response|
|import into cell|
|viral process|
|innate immune response|
|symbiotic process|
|interspecies interaction between organisms|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|integral component of plasma membrane|
|peptide transport|
|amide transport|
|intracellular signal transduction|
|nitrogen compound transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|1.87|
|[[:results:exp285|GW501516 25μM R06 exp285]]|2.36|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18393
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CLEC4M Expression in NALM6 Cells: 1.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>