CLPTM1 [The Human Chemical-Genetic Interaction Map Project]

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======= CLPTM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CLPTM1
  * **<color #00a2e8>Official Name</color>**: CLPTM1 regulator of GABA type A receptor forward trafficking
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1209|1209]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O96005|O96005]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CLPTM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CLPTM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604783|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in T-cell development. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CLPTM1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of T cell differentiation in thymus|
|regulation of T cell differentiation|
|regulation of lymphocyte differentiation|
|regulation of leukocyte differentiation|
|regulation of T cell activation|
|external side of plasma membrane|
|regulation of hemopoiesis|
|regulation of lymphocyte activation|
|regulation of leukocyte activation|
|regulation of cell activation|
|integral component of plasma membrane|
|regulation of immune system process|
|regulation of cell differentiation|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-1.97|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.84|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tceb3c|TCEB3C]]|0.47|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.46|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.446|
|[[:human genes:a:atxn1|ATXN1]]|0.425|
|[[:human genes:n:numa1|NUMA1]]|0.422|
|[[:human genes:a:atp13a1|ATP13A1]]|0.419|
|[[:human genes:p:pan2|PAN2]]|0.417|
|[[:human genes:v:vasn|VASN]]|0.413|
|[[:human genes:f:fdx1l|FDX1L]]|0.413|
|[[:human genes:p:psmc2|PSMC2]]|0.412|
|[[:human genes:p:psmd1|PSMD1]]|0.412|
|[[:human genes:h:hivep3|HIVEP3]]|0.409|
|[[:human genes:l:lrr1|LRR1]]|0.407|
|[[:human genes:w:wdr87|WDR87]]|0.406|
|[[:human genes:p:pan3|PAN3]]|0.404|
|[[:human genes:s:smg7|SMG7]]|0.401|
|[[:human genes:p:psmd11|PSMD11]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1608
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CLPTM1 Expression in NALM6 Cells: 6.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>