CLSPN [The Human Chemical-Genetic Interaction Map Project]

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======= CLSPN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CLSPN
  * **<color #00a2e8>Official Name</color>**: claspin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=63967|63967]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HAW4|Q9HAW4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CLSPN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CLSPN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605434|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR- dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S- phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks. {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|anaphase-promoting complex binding|
|mitotic DNA replication checkpoint|
|DNA replication checkpoint|
|mitotic G2 DNA damage checkpoint|
|mitotic G2/M transition checkpoint|
|G2 DNA damage checkpoint|
|negative regulation of G2/M transition of mitotic cell cycle|
|mitotic DNA damage checkpoint|
|negative regulation of cell cycle G2/M phase transition|
|mitotic DNA integrity checkpoint|
|DNA damage checkpoint|
|DNA integrity checkpoint|
|mitotic cell cycle checkpoint|
|peptidyl-serine phosphorylation|
|cell cycle checkpoint|
|regulation of G2/M transition of mitotic cell cycle|
|peptidyl-serine modification|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|DNA replication|
|negative regulation of cell cycle phase transition|
|protein deubiquitination|
|protein modification by small protein removal|
|negative regulation of mitotic cell cycle|
|negative regulation of cell cycle process|
|activation of protein kinase activity|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|DNA repair|
|positive regulation of protein kinase activity|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|positive regulation of transferase activity|
|mitotic cell cycle|
|DNA metabolic process|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|regulation of protein kinase activity|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|protein phosphorylation|
|regulation of transferase activity|
|Golgi apparatus|
|protein modification by small protein conjugation or removal|
|cell cycle process|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of cell cycle|
|positive regulation of protein modification process|
|proteolysis|
|phosphorylation|
|cell cycle|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|DNA binding|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-2.24|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.08|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.99|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.92|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-1.91|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-1.91|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|-1.9|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-1.86|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.84|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.79|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.74|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|1.75|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|1.79|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|1.8|
|[[:results:exp124|GSK343 3μM R03 exp124]]|1.8|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|1.82|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.85|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|1.88|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|1.9|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.92|
|[[:results:exp149|SB203580 25μM R03 exp149]]|1.96|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|2.51|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|2.83|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|3.31|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 46/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|2/28|
|bone|3/26|
|breast|2/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|1/20|
|lung|3/75|
|lymphocyte|2/16|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|6/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|2/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2005
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CLSPN Expression in NALM6 Cells: 7.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>