CLU [The Human Chemical-Genetic Interaction Map Project]

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======= CLU =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CLU
  * **<color #00a2e8>Official Name</color>**: clusterin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1191|1191]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10909|P10909]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CLU&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CLU|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/185430|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[provided by RefSeq, May 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress- induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation. {ECO:0000269|PubMed:11123922, ECO:0000269|PubMed:12047389, ECO:0000269|PubMed:12176985, ECO:0000269|PubMed:12551933, ECO:0000269|PubMed:12882985, ECO:0000269|PubMed:16113678, ECO:0000269|PubMed:17260971, ECO:0000269|PubMed:17407782, ECO:0000269|PubMed:17412999, ECO:0000269|PubMed:17689225, ECO:0000269|PubMed:19137541, ECO:0000269|PubMed:19535339, ECO:0000269|PubMed:19996109, ECO:0000269|PubMed:20068069, ECO:0000269|PubMed:21505792}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Clusterin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of neurofibrillary tangle assembly|
|negative regulation of cellular response to thapsigargin|
|negative regulation of cellular response to tunicamycin|
|regulation of cellular response to tunicamycin|
|regulation of neuronal signal transduction|
|perinuclear endoplasmic reticulum lumen|
|regulation of cellular response to thapsigargin|
|chaperone-mediated protein transport involved in chaperone-mediated autophagy|
|chromaffin granule|
|immune complex clearance|
|regulation of neurofibrillary tangle assembly|
|protein targeting to lysosome involved in chaperone-mediated autophagy|
|positive regulation of inclusion body assembly|
|protein targeting to vacuole involved in autophagy|
|positive regulation of amyloid fibril formation|
|central nervous system myelin maintenance|
|negative regulation of amyloid fibril formation|
|neurofibrillary tangle|
|positive regulation of tau-protein kinase activity|
|microglial cell proliferation|
|macrophage proliferation|
|regulation of amyloid fibril formation|
|chaperone-mediated autophagy|
|spherical high-density lipoprotein particle|
|negative regulation of protein homooligomerization|
|positive regulation of protein homooligomerization|
|chaperone-mediated protein transport|
|regulation of tau-protein kinase activity|
|negative regulation of amyloid-beta formation|
|myelin maintenance|
|negative regulation of amyloid precursor protein catabolic process|
|positive regulation of amyloid-beta formation|
|regulation of inclusion body assembly|
|regulation of amyloid-beta clearance|
|apical dendrite|
|glial cell proliferation|
|reverse cholesterol transport|
|negative regulation of protein oligomerization|
|chaperone-mediated protein complex assembly|
|positive regulation of amyloid precursor protein catabolic process|
|negative regulation of release of cytochrome c from mitochondria|
|central nervous system myelination|
|axon ensheathment in central nervous system|
|regulation of protein homooligomerization|
|protein targeting to lysosome|
|low-density lipoprotein particle receptor binding|
|release of cytochrome c from mitochondria|
|positive regulation of protein oligomerization|
|misfolded protein binding|
|response to misfolded protein|
|regulation of amyloid-beta formation|
|leukocyte activation involved in inflammatory response|
|microglial cell activation|
|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|regulation of amyloid precursor protein catabolic process|
|protein targeting to vacuole|
|protein localization to lysosome|
|cell periphery|
|glial cell activation|
|positive regulation of nitric oxide biosynthetic process|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|positive regulation of nitric oxide metabolic process|
|neuroinflammatory response|
|oligodendrocyte development|
|regulation of protein oligomerization|
|negative regulation of response to endoplasmic reticulum stress|
|tau protein binding|
|establishment of protein localization to vacuole|
|regulation of release of cytochrome c from mitochondria|
|macrophage activation|
|positive regulation of reactive oxygen species biosynthetic process|
|positive regulation of receptor-mediated endocytosis|
|negative regulation of mitochondrion organization|
|cholesterol transport|
|regulation of nitric oxide biosynthetic process|
|chaperone-mediated protein folding|
|protein transmembrane transport|
|apoptotic mitochondrial changes|
|protein localization to vacuole|
|sterol transport|
|platelet alpha granule lumen|
|oligodendrocyte differentiation|
|negative regulation of response to DNA damage stimulus|
|amyloid-beta binding|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|regulation of response to endoplasmic reticulum stress|
|positive regulation of tumor necrosis factor production|
|regulation of reactive oxygen species biosynthetic process|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of neuron death|
|plasma membrane organization|
|negative regulation of intrinsic apoptotic signaling pathway|
|positive regulation of reactive oxygen species metabolic process|
|leukocyte proliferation|
|positive regulation of ubiquitin-dependent protein catabolic process|
|regulation of receptor-mediated endocytosis|
|positive regulation of endocytosis|
|chaperone binding|
|positive regulation of proteasomal protein catabolic process|
|myelination|
|lysosomal transport|
|glial cell development|
|axon ensheathment|
|ensheathment of neurons|
|antimicrobial humoral response|
|regulation of complement activation|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|platelet degranulation|
|negative regulation of supramolecular fiber organization|
|negative regulation of protein complex assembly|
|unfolded protein binding|
|regulation of humoral immune response|
|organic hydroxy compound transport|
|positive regulation of cellular protein catabolic process|
|protein import|
|vacuolar transport|
|blood microparticle|
|negative regulation of cellular amide metabolic process|
|regulation of tumor necrosis factor production|
|positive regulation of cellular amide metabolic process|
|regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of NF-kappaB transcription factor activity|
|regulation of ubiquitin-dependent protein catabolic process|
|regulation of intrinsic apoptotic signaling pathway|
|complement activation, classical pathway|
|humoral immune response mediated by circulating immunoglobulin|
|glial cell differentiation|
|protein stabilization|
|regulation of reactive oxygen species metabolic process|
|regulation of mitochondrion organization|
|complement activation|
|regulation of proteasomal protein catabolic process|
|response to topologically incorrect protein|
|positive regulation of supramolecular fiber organization|
|regulation of endocytosis|
|immunoglobulin mediated immune response|
|B cell mediated immunity|
|gliogenesis|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|regulation of response to DNA damage stimulus|
|negative regulation of apoptotic signaling pathway|
|protein folding|
|ATPase activity|
|positive regulation of protein complex assembly|
|regulation of cellular protein catabolic process|
|process utilizing autophagic mechanism|
|autophagy|
|positive regulation of DNA-binding transcription factor activity|
|lymphocyte mediated immunity|
|protein-containing complex binding|
|synapse|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|response to virus|
|apoptotic signaling pathway|
|regulation of protein stability|
|ubiquitin protein ligase binding|
|lipid transport|
|regulation of neuron death|
|lipid localization|
|signaling receptor binding|
|humoral immune response|
|regulation of supramolecular fiber organization|
|regulation of neurotransmitter levels|
|positive regulation of proteolysis|
|protein targeting|
|collagen-containing extracellular matrix|
|positive regulation of cellular catabolic process|
|cytoskeleton|
|negative regulation of organelle organization|
|regulation of protein catabolic process|
|mitochondrial inner membrane|
|regulation of apoptotic signaling pathway|
|regulation of cellular amide metabolic process|
|endomembrane system organization|
|regulation of DNA-binding transcription factor activity|
|establishment of protein localization to organelle|
|positive regulation of catabolic process|
|mitochondrion organization|
|positive regulation of cytokine production|
|regulation of protein complex assembly|
|regulation of immune effector process|
|inflammatory response|
|negative regulation of intracellular signal transduction|
|positive regulation of cellular component biogenesis|
|positive regulation of protein kinase activity|
|regulation of vesicle-mediated transport|
|cell population proliferation|
|positive regulation of kinase activity|
|myeloid leukocyte activation|
|protein-containing complex|
|adaptive immune response|
|cell surface|
|activation of immune response|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of transferase activity|
|protein catabolic process|
|intracellular membrane-bounded organelle|
|regulation of cytokine production|
|perinuclear region of cytoplasm|
|positive regulation of cell death|
|regulated exocytosis|
|negative regulation of cellular component organization|
|cell morphogenesis|
|regulation of proteolysis|
|regulation of cellular response to stress|
|protein localization to organelle|
|leukocyte mediated immunity|
|innate immune response|
|exocytosis|
|regulation of protein kinase activity|
|cellular component morphogenesis|
|regulation of cellular catabolic process|
|cellular protein-containing complex assembly|
|membrane organization|
|positive regulation of immune response|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|leukocyte activation|
|defense response to other organism|
|regulation of cellular component biogenesis|
|regulation of transferase activity|
|central nervous system development|
|Golgi apparatus|
|positive regulation of transport|
|negative regulation of cell death|
|regulation of catabolic process|
|intracellular protein transport|
|secretion by cell|
|positive regulation of protein phosphorylation|
|export from cell|
|macromolecule catabolic process|
|programmed cell death|
|positive regulation of phosphorylation|
|organonitrogen compound catabolic process|
|cell activation|
|immune effector process|
|cell death|
|negative regulation of protein metabolic process|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of cellular component organization|
|lipid metabolic process|
|positive regulation of protein modification process|
|mitochondrion|
|negative regulation of signal transduction|
|transmembrane transport|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|extracellular space|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12802
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CLU Expression in NALM6 Cells: 2.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>