CNGA1 [The Human Chemical-Genetic Interaction Map Project]

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======= CNGA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CNGA1
  * **<color #00a2e8>Official Name</color>**: cyclic nucleotide gated channel subunit alpha 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1259|1259]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P29973|P29973]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CNGA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CNGA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/123825|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|cNMP binding|
|Ion trans|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intracellular cGMP-activated cation channel activity|
|intracellular cAMP-activated cation channel activity|
|rhodopsin mediated signaling pathway|
|cGMP binding|
|photoreceptor outer segment membrane|
|phototransduction, visible light|
|regulation of rhodopsin mediated signaling pathway|
|phototransduction|
|detection of visible light|
|detection of light stimulus|
|cellular response to light stimulus|
|detection of external stimulus|
|detection of abiotic stimulus|
|regulation of G protein-coupled receptor signaling pathway|
|cellular response to radiation|
|visual perception|
|sensory perception of light stimulus|
|response to light stimulus|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|response to radiation|
|cation transmembrane transport|
|detection of stimulus|
|cation transport|
|ion transmembrane transport|
|sensory perception|
|regulation of response to external stimulus|
|response to abiotic stimulus|
|transmembrane transport|
|G protein-coupled receptor signaling pathway|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|2.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11252
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CNGA1 Expression in NALM6 Cells: -0.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>