CNP [The Human Chemical-Genetic Interaction Map Project]

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======= CNP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CNP
  * **<color #00a2e8>Official Name</color>**: 2',3'-cyclic nucleotide 3' phosphodiesterase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1267|1267]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09543|P09543]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CNP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CNP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/123830|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CNPase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|2,3-cyclic-nucleotide 3-phosphodiesterase activity|
|cyclic nucleotide binding|
|myelin sheath abaxonal region|
|myelin sheath adaxonal region|
|cyclic nucleotide catabolic process|
|pseudopodium|
|cyclic nucleotide metabolic process|
|substantia nigra development|
|neural nucleus development|
|microvillus|
|nucleotide catabolic process|
|oligodendrocyte differentiation|
|regulation of mitochondrial membrane permeability|
|nucleoside phosphate catabolic process|
|adult locomotory behavior|
|regulation of membrane permeability|
|midbrain development|
|melanosome|
|nucleobase-containing small molecule biosynthetic process|
|organophosphate catabolic process|
|mitochondrial membrane organization|
|adult behavior|
|mitochondrial outer membrane|
|glial cell differentiation|
|locomotory behavior|
|gliogenesis|
|mitochondrial transport|
|aging|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|axonogenesis|
|nucleobase-containing compound catabolic process|
|forebrain development|
|mitochondrial inner membrane|
|axon development|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|cell morphogenesis involved in neuron differentiation|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|trans-synaptic signaling|
|mitochondrion organization|
|aromatic compound catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|synaptic signaling|
|microtubule cytoskeleton organization|
|neuron projection morphogenesis|
|organic cyclic compound catabolic process|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|response to toxic substance|
|cell part morphogenesis|
|nucleobase-containing small molecule metabolic process|
|cell morphogenesis involved in differentiation|
|behavior|
|small molecule biosynthetic process|
|neuron projection development|
|microtubule-based process|
|response to bacterium|
|perinuclear region of cytoplasm|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|cellular component morphogenesis|
|response to lipid|
|membrane organization|
|organophosphate metabolic process|
|central nervous system development|
|neuron differentiation|
|nucleobase-containing compound biosynthetic process|
|cytoskeleton organization|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|response to biotic stimulus|
|RNA binding|
|generation of neurons|
|response to oxygen-containing compound|
|extracellular space|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|cell development|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.97|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|-1.73|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12634
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CNP Expression in NALM6 Cells: 6.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>