CNTF [The Human Chemical-Genetic Interaction Map Project]

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======= CNTF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CNTF
  * **<color #00a2e8>Official Name</color>**: ciliary neurotrophic factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1270|1270]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P26441|P26441]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CNTF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CNTF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/118945|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CNTF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of retinal cell programmed cell death|
|ciliary neurotrophic factor receptor binding|
|ciliary neurotrophic factor-mediated signaling pathway|
|interleukin-6 receptor binding|
|positive regulation of axon regeneration|
|negative regulation of photoreceptor cell differentiation|
|positive regulation of neuron projection regeneration|
|regulation of photoreceptor cell differentiation|
|astrocyte activation|
|regulation of axon regeneration|
|regulation of neuron projection regeneration|
|astrocyte development|
|glial cell activation|
|neuroinflammatory response|
|astrocyte differentiation|
|positive regulation of response to wounding|
|positive regulation of tyrosine phosphorylation of STAT protein|
|regulation of tyrosine phosphorylation of STAT protein|
|positive regulation of receptor signaling pathway via JAK-STAT|
|muscle organ morphogenesis|
|positive regulation of receptor signaling pathway via STAT|
|glial cell development|
|regulation of receptor signaling pathway via JAK-STAT|
|regulation of receptor signaling pathway via STAT|
|negative regulation of neuron apoptotic process|
|growth factor activity|
|regulation of response to wounding|
|glial cell differentiation|
|cytokine activity|
|positive regulation of peptidyl-tyrosine phosphorylation|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|gliogenesis|
|negative regulation of neuron differentiation|
|regulation of peptidyl-tyrosine phosphorylation|
|regulation of animal organ morphogenesis|
|protein-containing complex binding|
|positive regulation of neuron projection development|
|negative regulation of neurogenesis|
|axon|
|muscle organ development|
|regulation of neuron death|
|negative regulation of nervous system development|
|negative regulation of cell development|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|positive regulation of neurogenesis|
|muscle structure development|
|regulation of neuron projection development|
|inflammatory response|
|positive regulation of nervous system development|
|positive regulation of cell development|
|positive regulation of response to external stimulus|
|regulation of neuron differentiation|
|cytokine-mediated signaling pathway|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|regulation of cellular response to stress|
|neuron development|
|regulation of neurogenesis|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|central nervous system development|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|regulation of response to external stimulus|
|response to cytokine|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|defense response|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|regulation of response to stress|
|generation of neurons|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|extracellular region|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15277
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CNTF Expression in NALM6 Cells: 1.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>