COG4 [The Human Chemical-Genetic Interaction Map Project]

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======= COG4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COG4
  * **<color #00a2e8>Official Name</color>**: component of oligomeric golgi complex 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25839|25839]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H9E3|Q9H9E3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COG4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COG4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606976|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a component of an oligomeric protein complex involved in the structure and function of the Golgi apparatus. Defects in this gene may be a cause of congenital disorder of glycosylation type IIj. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. {ECO:0000269|PubMed:19536132}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|COG4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Golgi vesicle prefusion complex stabilization|
|Golgi transport complex|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|trans-Golgi network membrane|
|Golgi organization|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|Golgi vesicle transport|
|endomembrane system organization|
|Golgi membrane|
|cellular protein-containing complex assembly|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.65|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.12|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|-2.07|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.91|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.88|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.83|
|[[:results:exp539|42°C R08 exp539]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cog1|COG1]]|0.538|
|[[:human genes:c:cog3|COG3]]|0.533|
|[[:human genes:p:pi4kb|PI4KB]]|0.491|
|[[:human genes:p:prim1|PRIM1]]|0.445|
|[[:human genes:c:cog8|COG8]]|0.444|
|[[:human genes:p:polr2j3|POLR2J3]]|0.444|
|[[:human genes:c:cog7|COG7]]|0.44|
|[[:human genes:a:arcn1|ARCN1]]|0.421|
|[[:human genes:p:psmb4|PSMB4]]|0.418|
|[[:human genes:p:polr1a|POLR1A]]|0.411|
|[[:human genes:o:osbp|OSBP]]|0.408|
|[[:human genes:v:vps54|VPS54]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 34/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|3/28|
|bone|3/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|2/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 699
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COG4 Expression in NALM6 Cells: 5.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>