COL3A1 [The Human Chemical-Genetic Interaction Map Project]

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======= COL3A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COL3A1
  * **<color #00a2e8>Official Name</color>**: collagen type III alpha 1 chain
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1281|1281]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P02461|P02461]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COL3A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COL3A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/120180|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|VWC|
|Collagen|
|COLFI|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|collagen type III trimer|
|aorta smooth muscle tissue morphogenesis|
|platelet-derived growth factor binding|
|negative regulation of neuron migration|
|smooth muscle tissue development|
|aorta morphogenesis|
|positive regulation of Rho protein signal transduction|
|extracellular matrix structural constituent conferring tensile strength|
|regulation of neuron migration|
|collagen fibril organization|
|aorta development|
|SMAD binding|
|peptide cross-linking|
|artery morphogenesis|
|positive regulation of Ras protein signal transduction|
|cellular response to amino acid stimulus|
|positive regulation of small GTPase mediated signal transduction|
|muscle tissue morphogenesis|
|artery development|
|muscle organ morphogenesis|
|integrin-mediated signaling pathway|
|transforming growth factor beta receptor signaling pathway|
|protease binding|
|response to amino acid|
|cerebral cortex development|
|cell-matrix adhesion|
|digestive tract development|
|integrin binding|
|extracellular matrix structural constituent|
|platelet activation|
|digestive system development|
|regulation of Rho protein signal transduction|
|negative regulation of immune response|
|cellular response to transforming growth factor beta stimulus|
|response to transforming growth factor beta|
|pallium development|
|cell-substrate adhesion|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|cellular response to acid chemical|
|response to mechanical stimulus|
|extracellular matrix|
|regulation of Ras protein signal transduction|
|telencephalon development|
|negative regulation of cell migration|
|negative regulation of cell motility|
|negative regulation of neurogenesis|
|blood coagulation|
|coagulation|
|muscle organ development|
|muscle tissue development|
|hemostasis|
|endoplasmic reticulum lumen|
|negative regulation of cellular component movement|
|negative regulation of nervous system development|
|negative regulation of locomotion|
|negative regulation of cell development|
|extracellular matrix organization|
|regulation of small GTPase mediated signal transduction|
|response to acid chemical|
|collagen-containing extracellular matrix|
|skin development|
|extracellular structure organization|
|forebrain development|
|blood vessel morphogenesis|
|response to radiation|
|negative regulation of immune system process|
|supramolecular fiber organization|
|muscle structure development|
|wound healing|
|blood vessel development|
|skeletal system development|
|regulation of body fluid levels|
|cellular response to growth factor stimulus|
|vasculature development|
|cardiovascular system development|
|heart development|
|response to growth factor|
|tissue morphogenesis|
|response to wounding|
|cellular response to organonitrogen compound|
|tube morphogenesis|
|cellular response to nitrogen compound|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|brain development|
|head development|
|regulation of neurogenesis|
|tube development|
|regulation of cell migration|
|circulatory system development|
|regulation of cell motility|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|animal organ morphogenesis|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|response to organonitrogen compound|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|cell activation|
|response to nitrogen compound|
|response to cytokine|
|regulation of immune response|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|response to endogenous stimulus|
|generation of neurons|
|response to oxygen-containing compound|
|extracellular space|
|negative regulation of response to stimulus|
|neurogenesis|
|regulation of immune system process|
|positive regulation of signal transduction|
|tissue development|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.83|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-1.81|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3495
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COL3A1 Expression in NALM6 Cells: -6.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>