COPS7B [The Human Chemical-Genetic Interaction Map Project]

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======= COPS7B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COPS7B
  * **<color #00a2e8>Official Name</color>**: COP9 signalosome subunit 7B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64708|64708]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H9Q2|Q9H9Q2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COPS7B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COPS7B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616010|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PCI|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|COP9 signalosome assembly|
|protein deneddylation|
|nucleotide-excision repair, DNA damage recognition|
|COP9 signalosome|
|transcription-coupled nucleotide-excision repair|
|nucleotide-excision repair|
|protein modification by small protein removal|
|post-translational protein modification|
|DNA repair|
|viral process|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|symbiotic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|protein modification by small protein conjugation or removal|
|chromosome organization|
|proteolysis|
|protein-containing complex assembly|
|cellular response to stress|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|-2.42|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.38|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.24|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-2.19|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-2.15|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.05|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.02|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.01|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.96|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.9|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-1.88|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.81|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-1.77|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|1.8|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.97|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.16|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|2.18|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|2.22|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.23|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.25|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|2.39|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.53|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.94|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|3.08|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|3.48|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|3.6|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|3.76|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|4.03|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|5.28|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|5.57|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|7.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cops8|COPS8]]|0.597|
|[[:human genes:c:cops4|COPS4]]|0.53|
|[[:human genes:c:cops2|COPS2]]|0.516|
|[[:human genes:c:cops5|COPS5]]|0.514|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10396
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COPS7B Expression in NALM6 Cells: 6.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>