COQ3 [The Human Chemical-Genetic Interaction Map Project]

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======= COQ3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COQ3
  * **<color #00a2e8>Official Name</color>**: coenzyme Q3, methyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51805|51805]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NZJ6|Q9NZJ6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COQ3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COQ3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605196|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. {ECO:0000255|HAMAP- Rule:MF_03190}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Methyltransf 11|
|CMAS|
|Methyltransf 18|
|Ubie methyltran|
|Methyltransf 12|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|3-demethylubiquinone-9 3-O-methyltransferase activity|
|2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity|
|hexaprenyldihydroxybenzoate methyltransferase activity|
|decaprenyldihydroxybenzoate methyltransferase activity|
|3-demethylubiquinone-10 3-O-methyltransferase activity|
|3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity|
|regulation of ubiquinone biosynthetic process|
|O-methyltransferase activity|
|regulation of coenzyme metabolic process|
|extrinsic component of mitochondrial inner membrane|
|quinone biosynthetic process|
|regulation of ketone biosynthetic process|
|ubiquinone biosynthetic process|
|ubiquinone metabolic process|
|glycerol metabolic process|
|alditol metabolic process|
|ketone biosynthetic process|
|quinone metabolic process|
|regulation of cofactor metabolic process|
|oxidoreduction coenzyme metabolic process|
|cellular ketone metabolic process|
|polyol metabolic process|
|coenzyme biosynthetic process|
|cellular carbohydrate metabolic process|
|regulation of cellular ketone metabolic process|
|cofactor biosynthetic process|
|coenzyme metabolic process|
|methylation|
|alcohol metabolic process|
|mitochondrial matrix|
|regulation of small molecule metabolic process|
|cofactor metabolic process|
|organic hydroxy compound metabolic process|
|carbohydrate metabolic process|
|small molecule biosynthetic process|
|mitochondrion|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|1.75|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.81|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|1.9|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.03|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.11|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.44|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.68|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:coq6|COQ6]]|0.579|
|[[:human genes:m:mrpl21|MRPL21]]|0.553|
|[[:human genes:c:coq2|COQ2]]|0.544|
|[[:human genes:t:timm8b|TIMM8B]]|0.542|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.53|
|[[:human genes:m:mrps18a|MRPS18A]]|0.527|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.515|
|[[:human genes:c:coq7|COQ7]]|0.511|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.506|
|[[:human genes:m:mrpl23|MRPL23]]|0.505|
|[[:human genes:y:yars2|YARS2]]|0.501|
|[[:human genes:s:slc25a26|SLC25A26]]|0.498|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.495|
|[[:human genes:m:mrps34|MRPS34]]|0.493|
|[[:human genes:o:opa1|OPA1]]|0.488|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.487|
|[[:human genes:d:dnlz|DNLZ]]|0.485|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.483|
|[[:human genes:v:vars2|VARS2]]|0.481|
|[[:human genes:t:tars2|TARS2]]|0.477|
|[[:human genes:t:timm17a|TIMM17A]]|0.476|
|[[:human genes:d:dap3|DAP3]]|0.475|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.473|
|[[:human genes:g:gfm1|GFM1]]|0.472|
|[[:human genes:c:c12orf65|C12orf65]]|0.472|
|[[:human genes:t:taz|TAZ]]|0.47|
|[[:human genes:m:mrp63|MRP63]]|0.47|
|[[:human genes:n:ndufb11|NDUFB11]]|0.469|
|[[:human genes:p:pdss1|PDSS1]]|0.469|
|[[:human genes:r:rpusd4|RPUSD4]]|0.468|
|[[:human genes:t:triap1|TRIAP1]]|0.467|
|[[:human genes:c:crls1|CRLS1]]|0.467|
|[[:human genes:s:selrc1|SELRC1]]|0.466|
|[[:human genes:m:mrps5|MRPS5]]|0.465|
|[[:human genes:c:c17orf89|C17orf89]]|0.465|
|[[:human genes:m:mrps10|MRPS10]]|0.464|
|[[:human genes:t:tefm|TEFM]]|0.463|
|[[:human genes:u:uqcc2|UQCC2]]|0.46|
|[[:human genes:p:pitrm1|PITRM1]]|0.459|
|[[:human genes:m:mrps24|MRPS24]]|0.457|
|[[:human genes:m:mtg1|MTG1]]|0.456|
|[[:human genes:m:mtpap|MTPAP]]|0.454|
|[[:human genes:n:ndufa3|NDUFA3]]|0.452|
|[[:human genes:d:dhx30|DHX30]]|0.449|
|[[:human genes:p:pars2|PARS2]]|0.448|
|[[:human genes:m:mtg2|MTG2]]|0.448|
|[[:human genes:n:nars2|NARS2]]|0.446|
|[[:human genes:m:mrpl44|MRPL44]]|0.444|
|[[:human genes:r:romo1|ROMO1]]|0.443|
|[[:human genes:w:wbscr16|WBSCR16]]|0.443|
|[[:human genes:e:ears2|EARS2]]|0.443|
|[[:human genes:i:iba57|IBA57]]|0.443|
|[[:human genes:m:mrpl53|MRPL53]]|0.442|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.442|
|[[:human genes:t:tmem242|TMEM242]]|0.441|
|[[:human genes:q:qrsl1|QRSL1]]|0.439|
|[[:human genes:a:aars2|AARS2]]|0.439|
|[[:human genes:p:ptpmt1|PTPMT1]]|0.438|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.438|
|[[:human genes:f:fastkd5|FASTKD5]]|0.437|
|[[:human genes:p:pnpt1|PNPT1]]|0.436|
|[[:human genes:p:pgp|PGP]]|0.436|
|[[:human genes:m:mrps16|MRPS16]]|0.433|
|[[:human genes:m:mrps6|MRPS6]]|0.433|
|[[:human genes:m:mrps12|MRPS12]]|0.432|
|[[:human genes:m:mrps21|MRPS21]]|0.431|
|[[:human genes:a:alas1|ALAS1]]|0.431|
|[[:human genes:t:trub2|TRUB2]]|0.431|
|[[:human genes:b:bcs1l|BCS1L]]|0.43|
|[[:human genes:m:mtif3|MTIF3]]|0.43|
|[[:human genes:g:gatc|GATC]]|0.428|
|[[:human genes:g:glrx5|GLRX5]]|0.428|
|[[:human genes:s:sco2|SCO2]]|0.428|
|[[:human genes:c:coq5|COQ5]]|0.426|
|[[:human genes:m:mrps11|MRPS11]]|0.424|
|[[:human genes:m:mrpl55|MRPL55]]|0.424|
|[[:human genes:l:lars2|LARS2]]|0.423|
|[[:human genes:g:gfm2|GFM2]]|0.422|
|[[:human genes:t:tomm20|TOMM20]]|0.422|
|[[:human genes:m:mrpl12|MRPL12]]|0.421|
|[[:human genes:r:rpe|RPE]]|0.42|
|[[:human genes:r:rbfa|RBFA]]|0.414|
|[[:human genes:w:wars2|WARS2]]|0.413|
|[[:human genes:f:fech|FECH]]|0.412|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.411|
|[[:human genes:c:coa6|COA6]]|0.406|
|[[:human genes:t:tomm40|TOMM40]]|0.406|
|[[:human genes:f:ftsj2|FTSJ2]]|0.405|
|[[:human genes:m:mcat|MCAT]]|0.405|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.404|
|[[:human genes:t:tufm|TUFM]]|0.404|
|[[:human genes:c:c10orf2|C10orf2]]|0.402|
|[[:human genes:p:pgls|PGLS]]|0.402|
|[[:human genes:m:mrps9|MRPS9]]|0.402|
|[[:human genes:p:pgm3|PGM3]]|0.402|
|[[:human genes:a:atp5a1|ATP5A1]]|0.4|
|[[:human genes:p:ptrhd1|PTRHD1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2065
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COQ3 Expression in NALM6 Cells: 3.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>