COX16 [The Human Chemical-Genetic Interaction Map Project]

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======= COX16 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COX16
  * **<color #00a2e8>Official Name</color>**: cytochrome c oxidase assembly factor COX16
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51241|51241]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P0S2|Q9P0S2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COX16&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COX16|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618064|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial respiratory chain complex IV assembly|
|respiratory chain complex IV assembly|
|cytochrome complex assembly|
|integral component of mitochondrial inner membrane|
|mitochondrial respiratory chain complex assembly|
|mitochondrion organization|
|molecular function|
|cellular protein-containing complex assembly|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-2.06|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.9|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-1.89|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-1.8|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|-1.75|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-1.73|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-1.72|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.7|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.7|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.73|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.73|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.75|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.95|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.07|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.1|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.57|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hsd17b10|HSD17B10]]|0.721|
|[[:human genes:m:mrpl21|MRPL21]]|0.713|
|[[:human genes:s:sco2|SCO2]]|0.698|
|[[:human genes:m:mrps16|MRPS16]]|0.69|
|[[:human genes:d:dap3|DAP3]]|0.687|
|[[:human genes:s:selrc1|SELRC1]]|0.681|
|[[:human genes:y:yars2|YARS2]]|0.681|
|[[:human genes:m:mrps21|MRPS21]]|0.672|
|[[:human genes:d:dars2|DARS2]]|0.667|
|[[:human genes:b:bcs1l|BCS1L]]|0.665|
|[[:human genes:t:tars2|TARS2]]|0.665|
|[[:human genes:f:fastkd5|FASTKD5]]|0.663|
|[[:human genes:m:mrpl23|MRPL23]]|0.661|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.657|
|[[:human genes:h:hars2|HARS2]]|0.653|
|[[:human genes:m:mrps6|MRPS6]]|0.652|
|[[:human genes:m:mrps14|MRPS14]]|0.651|
|[[:human genes:m:mrpl47|MRPL47]]|0.646|
|[[:human genes:m:mrps26|MRPS26]]|0.644|
|[[:human genes:m:mrps5|MRPS5]]|0.643|
|[[:human genes:r:rpusd4|RPUSD4]]|0.642|
|[[:human genes:s:sars2|SARS2]]|0.64|
|[[:human genes:v:vars2|VARS2]]|0.638|
|[[:human genes:m:mrps34|MRPS34]]|0.636|
|[[:human genes:m:mrpl53|MRPL53]]|0.631|
|[[:human genes:g:gfm1|GFM1]]|0.631|
|[[:human genes:n:nars2|NARS2]]|0.63|
|[[:human genes:e:ears2|EARS2]]|0.627|
|[[:human genes:s:slc25a26|SLC25A26]]|0.627|
|[[:human genes:m:mrp63|MRP63]]|0.626|
|[[:human genes:q:qrsl1|QRSL1]]|0.623|
|[[:human genes:c:cox7b|COX7B]]|0.618|
|[[:human genes:m:mrps18a|MRPS18A]]|0.616|
|[[:human genes:m:mtg2|MTG2]]|0.608|
|[[:human genes:t:tufm|TUFM]]|0.606|
|[[:human genes:r:rars2|RARS2]]|0.606|
|[[:human genes:p:pars2|PARS2]]|0.6|
|[[:human genes:c:cox17|COX17]]|0.599|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.597|
|[[:human genes:n:ndufa3|NDUFA3]]|0.596|
|[[:human genes:m:mrps2|MRPS2]]|0.595|
|[[:human genes:c:coa3|COA3]]|0.594|
|[[:human genes:r:rbfa|RBFA]]|0.591|
|[[:human genes:l:lars2|LARS2]]|0.589|
|[[:human genes:c:c12orf65|C12orf65]]|0.585|
|[[:human genes:c:coa6|COA6]]|0.583|
|[[:human genes:f:fars2|FARS2]]|0.582|
|[[:human genes:m:mtpap|MTPAP]]|0.581|
|[[:human genes:g:gatc|GATC]]|0.58|
|[[:human genes:m:mrps24|MRPS24]]|0.574|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.574|
|[[:human genes:m:mrpl20|MRPL20]]|0.57|
|[[:human genes:w:wbscr16|WBSCR16]]|0.57|
|[[:human genes:m:mrps23|MRPS23]]|0.569|
|[[:human genes:c:cox11|COX11]]|0.567|
|[[:human genes:p:pnpt1|PNPT1]]|0.567|
|[[:human genes:m:mrpl45|MRPL45]]|0.565|
|[[:human genes:g:gfm2|GFM2]]|0.564|
|[[:human genes:m:mars2|MARS2]]|0.563|
|[[:human genes:m:mrpl36|MRPL36]]|0.56|
|[[:human genes:p:pdss1|PDSS1]]|0.558|
|[[:human genes:p:pet100|PET100]]|0.558|
|[[:human genes:m:mrps9|MRPS9]]|0.558|
|[[:human genes:c:coa5|COA5]]|0.557|
|[[:human genes:m:mrps25|MRPS25]]|0.557|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.554|
|[[:human genes:a:atp5b|ATP5B]]|0.551|
|[[:human genes:a:aars2|AARS2]]|0.55|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.545|
|[[:human genes:a:atp5d|ATP5D]]|0.543|
|[[:human genes:m:mrpl15|MRPL15]]|0.543|
|[[:human genes:n:ndufc2|NDUFC2]]|0.537|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.537|
|[[:human genes:t:trub2|TRUB2]]|0.533|
|[[:human genes:t:triap1|TRIAP1]]|0.532|
|[[:human genes:c:cox5a|COX5A]]|0.532|
|[[:human genes:t:tmem242|TMEM242]]|0.531|
|[[:human genes:e:elac2|ELAC2]]|0.53|
|[[:human genes:p:polg2|POLG2]]|0.529|
|[[:human genes:u:uqcr10|UQCR10]]|0.528|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.528|
|[[:human genes:c:c10orf2|C10orf2]]|0.527|
|[[:human genes:c:cox15|COX15]]|0.527|
|[[:human genes:m:mrps10|MRPS10]]|0.526|
|[[:human genes:c:cox6b1|COX6B1]]|0.525|
|[[:human genes:m:mrpl44|MRPL44]]|0.525|
|[[:human genes:c:cox6c|COX6C]]|0.524|
|[[:human genes:m:mrps12|MRPS12]]|0.524|
|[[:human genes:a:atp5a1|ATP5A1]]|0.522|
|[[:human genes:t:tefm|TEFM]]|0.522|
|[[:human genes:c:c17orf89|C17orf89]]|0.521|
|[[:human genes:n:ndufb5|NDUFB5]]|0.519|
|[[:human genes:d:dhx30|DHX30]]|0.514|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.513|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.511|
|[[:human genes:m:mrpl42|MRPL42]]|0.51|
|[[:human genes:m:mrpl27|MRPL27]]|0.505|
|[[:human genes:p:pet112|PET112]]|0.503|
|[[:human genes:p:pet117|PET117]]|0.502|
|[[:human genes:a:aifm1|AIFM1]]|0.501|
|[[:human genes:m:mrpl12|MRPL12]]|0.497|
|[[:human genes:m:mrpl18|MRPL18]]|0.495|
|[[:human genes:r:rpusd3|RPUSD3]]|0.495|
|[[:human genes:m:mrps11|MRPS11]]|0.494|
|[[:human genes:n:ndufb11|NDUFB11]]|0.494|
|[[:human genes:m:mrpl33|MRPL33]]|0.491|
|[[:human genes:u:uqcrq|UQCRQ]]|0.49|
|[[:human genes:c:coq4|COQ4]]|0.489|
|[[:human genes:c:coq2|COQ2]]|0.489|
|[[:human genes:c:chchd4|CHCHD4]]|0.488|
|[[:human genes:f:ftsj2|FTSJ2]]|0.487|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.486|
|[[:human genes:a:atp5c1|ATP5C1]]|0.485|
|[[:human genes:h:hccs|HCCS]]|0.483|
|[[:human genes:t:tomm40|TOMM40]]|0.481|
|[[:human genes:p:pmm2|PMM2]]|0.475|
|[[:human genes:t:tfam|TFAM]]|0.475|
|[[:human genes:a:atp5j|ATP5J]]|0.475|
|[[:human genes:m:mrpl13|MRPL13]]|0.475|
|[[:human genes:m:mettl17|METTL17]]|0.474|
|[[:human genes:t:trmt10c|TRMT10C]]|0.473|
|[[:human genes:m:mrps22|MRPS22]]|0.473|
|[[:human genes:t:tpk1|TPK1]]|0.473|
|[[:human genes:t:timm8b|TIMM8B]]|0.472|
|[[:human genes:m:mrpl34|MRPL34]]|0.471|
|[[:human genes:c:cox7c|COX7C]]|0.471|
|[[:human genes:n:ndufa2|NDUFA2]]|0.47|
|[[:human genes:m:mrpl55|MRPL55]]|0.47|
|[[:human genes:m:mrpl3|MRPL3]]|0.469|
|[[:human genes:m:mrps33|MRPS33]]|0.469|
|[[:human genes:c:chchd1|CHCHD1]]|0.469|
|[[:human genes:c:cycs|CYCS]]|0.467|
|[[:human genes:m:mtg1|MTG1]]|0.464|
|[[:human genes:n:ndufb3|NDUFB3]]|0.464|
|[[:human genes:n:ndufa1|NDUFA1]]|0.463|
|[[:human genes:a:atp5o|ATP5O]]|0.463|
|[[:human genes:u:uqcrc1|UQCRC1]]|0.458|
|[[:human genes:t:tomm20|TOMM20]]|0.457|
|[[:human genes:f:fh|FH]]|0.456|
|[[:human genes:m:mrpl41|MRPL41]]|0.456|
|[[:human genes:m:mrpl43|MRPL43]]|0.456|
|[[:human genes:l:lsm10|LSM10]]|0.455|
|[[:human genes:e:ecsit|ECSIT]]|0.455|
|[[:human genes:a:atp5h|ATP5H]]|0.453|
|[[:human genes:c:cars2|CARS2]]|0.453|
|[[:human genes:d:dpagt1|DPAGT1]]|0.452|
|[[:human genes:p:polrmt|POLRMT]]|0.451|
|[[:human genes:a:atxn10|ATXN10]]|0.451|
|[[:human genes:t:tomm22|TOMM22]]|0.45|
|[[:human genes:h:higd2a|HIGD2A]]|0.449|
|[[:human genes:m:mrps7|MRPS7]]|0.448|
|[[:human genes:m:mrps28|MRPS28]]|0.447|
|[[:human genes:n:ndufa11|NDUFA11]]|0.446|
|[[:human genes:z:zrsr2|ZRSR2]]|0.446|
|[[:human genes:p:ppcs|PPCS]]|0.444|
|[[:human genes:m:mtif3|MTIF3]]|0.443|
|[[:human genes:m:mrpl11|MRPL11]]|0.443|
|[[:human genes:c:cox10|COX10]]|0.443|
|[[:human genes:s:sco1|SCO1]]|0.443|
|[[:human genes:t:tamm41|TAMM41]]|0.443|
|[[:human genes:s:slc25a3|SLC25A3]]|0.443|
|[[:human genes:n:ndufb6|NDUFB6]]|0.443|
|[[:human genes:m:mrpl39|MRPL39]]|0.443|
|[[:human genes:a:atp5f1|ATP5F1]]|0.442|
|[[:human genes:m:mrpl4|MRPL4]]|0.442|
|[[:human genes:n:ndufv1|NDUFV1]]|0.441|
|[[:human genes:p:pgm3|PGM3]]|0.439|
|[[:human genes:t:tmem126b|TMEM126B]]|0.439|
|[[:human genes:s:slc25a19|SLC25A19]]|0.438|
|[[:human genes:c:cox20|COX20]]|0.437|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.437|
|[[:human genes:p:polg|POLG]]|0.437|
|[[:human genes:r:rpia|RPIA]]|0.437|
|[[:human genes:n:nfu1|NFU1]]|0.437|
|[[:human genes:o:opa1|OPA1]]|0.437|
|[[:human genes:t:thg1l|THG1L]]|0.435|
|[[:human genes:d:dhrsx|DHRSX]]|0.433|
|[[:human genes:a:atp5sl|ATP5SL]]|0.433|
|[[:human genes:c:crls1|CRLS1]]|0.432|
|[[:human genes:n:ndufs7|NDUFS7]]|0.428|
|[[:human genes:m:mterfd2|MTERFD2]]|0.427|
|[[:human genes:m:mterfd1|MTERFD1]]|0.427|
|[[:human genes:s:sdha|SDHA]]|0.425|
|[[:human genes:m:mtfmt|MTFMT]]|0.424|
|[[:human genes:m:mrps35|MRPS35]]|0.423|
|[[:human genes:n:ndufb9|NDUFB9]]|0.422|
|[[:human genes:n:ndufa10|NDUFA10]]|0.419|
|[[:human genes:a:atp5e|ATP5E]]|0.419|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.417|
|[[:human genes:g:gfer|GFER]]|0.416|
|[[:human genes:p:ppa2|PPA2]]|0.416|
|[[:human genes:m:mrpl51|MRPL51]]|0.415|
|[[:human genes:m:mipep|MIPEP]]|0.415|
|[[:human genes:l:lrpprc|LRPPRC]]|0.414|
|[[:human genes:a:alg8|ALG8]]|0.412|
|[[:human genes:t:tfb1m|TFB1M]]|0.411|
|[[:human genes:i:isca2|ISCA2]]|0.411|
|[[:human genes:a:atic|ATIC]]|0.41|
|[[:human genes:a:alg6|ALG6]]|0.409|
|[[:human genes:c:coq5|COQ5]]|0.409|
|[[:human genes:m:mrpl52|MRPL52]]|0.408|
|[[:human genes:u:uap1|UAP1]]|0.408|
|[[:human genes:m:mrpl22|MRPL22]]|0.408|
|[[:human genes:a:atp5l|ATP5L]]|0.407|
|[[:human genes:s:ssbp1|SSBP1]]|0.407|
|[[:human genes:c:clpp|CLPP]]|0.406|
|[[:human genes:m:mrpl35|MRPL35]]|0.405|
|[[:human genes:m:mrpl2|MRPL2]]|0.405|
|[[:human genes:m:mrpl32|MRPL32]]|0.404|
|[[:human genes:m:mrpl38|MRPL38]]|0.404|
|[[:human genes:n:ndufs2|NDUFS2]]|0.404|
|[[:human genes:g:gars|GARS]]|0.403|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2558
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COX16 Expression in NALM6 Cells: 3.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>