COX7B [The Human Chemical-Genetic Interaction Map Project]

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======= COX7B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COX7B
  * **<color #00a2e8>Official Name</color>**: cytochrome c oxidase subunit 7B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1349|1349]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P24311|P24311]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COX7B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COX7B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300885|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIb, which is highly similar to bovine COX VIIb protein and is found in all tissues. This gene may have several pseudogenes on chromosomes 1, 2, 20 and 22. [provided by RefSeq, Jun 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Plays a role in proper central nervous system (CNS) development in vertebrates. {ECO:0000269|PubMed:23122588}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|COX7B|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|respiratory chain complex IV|
|mitochondrial respirasome|
|aerobic electron transport chain|
|mitochondrial electron transport, cytochrome c to oxygen|
|cytochrome-c oxidase activity|
|aerobic respiration|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|respiratory electron transport chain|
|oxidative phosphorylation|
|proton transmembrane transport|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial inner membrane|
|monovalent inorganic cation transport|
|generation of precursor metabolites and energy|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|inorganic ion transmembrane transport|
|cation transport|
|ion transmembrane transport|
|oxidation-reduction process|
|central nervous system development|
|transmembrane transport|
|phosphorylation|
|ion transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp401|SNS-032 25μM R07 exp401]]|1.72|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.76|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.87|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.2|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.3|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.98|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|3.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:q:qrsl1|QRSL1]]|0.62|
|[[:human genes:c:cox16|COX16]]|0.618|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.616|
|[[:human genes:b:bcs1l|BCS1L]]|0.615|
|[[:human genes:s:selrc1|SELRC1]]|0.602|
|[[:human genes:f:fastkd5|FASTKD5]]|0.596|
|[[:human genes:m:mrpl23|MRPL23]]|0.594|
|[[:human genes:y:yars2|YARS2]]|0.592|
|[[:human genes:d:dap3|DAP3]]|0.591|
|[[:human genes:s:sco2|SCO2]]|0.591|
|[[:human genes:m:mrpl21|MRPL21]]|0.587|
|[[:human genes:m:mrps6|MRPS6]]|0.585|
|[[:human genes:m:mrps26|MRPS26]]|0.583|
|[[:human genes:d:dars2|DARS2]]|0.581|
|[[:human genes:v:vars2|VARS2]]|0.578|
|[[:human genes:n:nars2|NARS2]]|0.569|
|[[:human genes:m:mrps21|MRPS21]]|0.568|
|[[:human genes:s:sars2|SARS2]]|0.563|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.562|
|[[:human genes:r:rars2|RARS2]]|0.561|
|[[:human genes:e:ears2|EARS2]]|0.559|
|[[:human genes:m:mrp63|MRP63]]|0.557|
|[[:human genes:g:gfm1|GFM1]]|0.554|
|[[:human genes:c:coa3|COA3]]|0.554|
|[[:human genes:r:rpusd4|RPUSD4]]|0.544|
|[[:human genes:m:mrps16|MRPS16]]|0.543|
|[[:human genes:m:mrpl47|MRPL47]]|0.541|
|[[:human genes:m:mrps5|MRPS5]]|0.536|
|[[:human genes:m:mars2|MARS2]]|0.536|
|[[:human genes:m:mtpap|MTPAP]]|0.536|
|[[:human genes:m:mrps25|MRPS25]]|0.535|
|[[:human genes:m:mrps24|MRPS24]]|0.534|
|[[:human genes:m:mrps18a|MRPS18A]]|0.527|
|[[:human genes:t:tars2|TARS2]]|0.524|
|[[:human genes:m:mrps14|MRPS14]]|0.524|
|[[:human genes:p:pars2|PARS2]]|0.519|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.518|
|[[:human genes:t:tufm|TUFM]]|0.517|
|[[:human genes:f:fars2|FARS2]]|0.516|
|[[:human genes:w:wbscr16|WBSCR16]]|0.516|
|[[:human genes:m:mrpl15|MRPL15]]|0.516|
|[[:human genes:h:hars2|HARS2]]|0.511|
|[[:human genes:g:gatc|GATC]]|0.509|
|[[:human genes:c:cox15|COX15]]|0.508|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.507|
|[[:human genes:m:mrpl20|MRPL20]]|0.503|
|[[:human genes:m:mrps34|MRPS34]]|0.5|
|[[:human genes:c:cox17|COX17]]|0.499|
|[[:human genes:c:coa5|COA5]]|0.499|
|[[:human genes:t:tfam|TFAM]]|0.498|
|[[:human genes:t:trub2|TRUB2]]|0.498|
|[[:human genes:m:mtg2|MTG2]]|0.496|
|[[:human genes:m:mrpl18|MRPL18]]|0.496|
|[[:human genes:p:pnpt1|PNPT1]]|0.495|
|[[:human genes:m:mrps23|MRPS23]]|0.494|
|[[:human genes:n:ndufb11|NDUFB11]]|0.491|
|[[:human genes:a:atp5d|ATP5D]]|0.488|
|[[:human genes:a:atp5b|ATP5B]]|0.488|
|[[:human genes:r:rbfa|RBFA]]|0.487|
|[[:human genes:m:mrpl3|MRPL3]]|0.486|
|[[:human genes:p:pdss1|PDSS1]]|0.486|
|[[:human genes:m:mrps12|MRPS12]]|0.485|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.484|
|[[:human genes:a:aars2|AARS2]]|0.483|
|[[:human genes:m:mrps2|MRPS2]]|0.483|
|[[:human genes:a:atp5a1|ATP5A1]]|0.482|
|[[:human genes:m:mrpl53|MRPL53]]|0.48|
|[[:human genes:p:pet117|PET117]]|0.478|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.478|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.474|
|[[:human genes:m:mrps9|MRPS9]]|0.473|
|[[:human genes:c:c10orf2|C10orf2]]|0.473|
|[[:human genes:l:lars2|LARS2]]|0.472|
|[[:human genes:m:mrpl45|MRPL45]]|0.471|
|[[:human genes:c:coa6|COA6]]|0.471|
|[[:human genes:c:cox6b1|COX6B1]]|0.47|
|[[:human genes:c:cox6c|COX6C]]|0.469|
|[[:human genes:n:ndufa3|NDUFA3]]|0.467|
|[[:human genes:c:cox11|COX11]]|0.466|
|[[:human genes:s:slc25a26|SLC25A26]]|0.464|
|[[:human genes:l:lrpprc|LRPPRC]]|0.463|
|[[:human genes:m:mrpl17|MRPL17]]|0.461|
|[[:human genes:f:ftsj2|FTSJ2]]|0.457|
|[[:human genes:a:aifm1|AIFM1]]|0.456|
|[[:human genes:m:mrps10|MRPS10]]|0.456|
|[[:human genes:u:uqcrq|UQCRQ]]|0.455|
|[[:human genes:t:tmem242|TMEM242]]|0.455|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.454|
|[[:human genes:m:mrpl33|MRPL33]]|0.452|
|[[:human genes:u:uqcr10|UQCR10]]|0.45|
|[[:human genes:a:atp5c1|ATP5C1]]|0.45|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.449|
|[[:human genes:f:fh|FH]]|0.447|
|[[:human genes:a:atp5o|ATP5O]]|0.447|
|[[:human genes:g:gfm2|GFM2]]|0.445|
|[[:human genes:t:triap1|TRIAP1]]|0.441|
|[[:human genes:h:higd2a|HIGD2A]]|0.441|
|[[:human genes:m:mrps22|MRPS22]]|0.441|
|[[:human genes:r:rpusd3|RPUSD3]]|0.44|
|[[:human genes:n:ndufc2|NDUFC2]]|0.44|
|[[:human genes:c:c12orf65|C12orf65]]|0.438|
|[[:human genes:m:mrpl44|MRPL44]]|0.437|
|[[:human genes:n:ndufa1|NDUFA1]]|0.431|
|[[:human genes:m:mrps7|MRPS7]]|0.431|
|[[:human genes:m:mrpl43|MRPL43]]|0.429|
|[[:human genes:m:mrpl32|MRPL32]]|0.429|
|[[:human genes:m:mrpl12|MRPL12]]|0.429|
|[[:human genes:t:tefm|TEFM]]|0.429|
|[[:human genes:m:mrpl36|MRPL36]]|0.428|
|[[:human genes:h:hccs|HCCS]]|0.428|
|[[:human genes:m:mrpl34|MRPL34]]|0.428|
|[[:human genes:m:mtif3|MTIF3]]|0.428|
|[[:human genes:c:c17orf89|C17orf89]]|0.425|
|[[:human genes:m:mrps11|MRPS11]]|0.423|
|[[:human genes:u:uqcrc1|UQCRC1]]|0.423|
|[[:human genes:a:atp5j|ATP5J]]|0.423|
|[[:human genes:n:ndufa2|NDUFA2]]|0.42|
|[[:human genes:s:slc25a3|SLC25A3]]|0.418|
|[[:human genes:e:elac2|ELAC2]]|0.418|
|[[:human genes:n:ndufb5|NDUFB5]]|0.418|
|[[:human genes:c:cox20|COX20]]|0.416|
|[[:human genes:m:mterfd1|MTERFD1]]|0.415|
|[[:human genes:m:mrpl11|MRPL11]]|0.414|
|[[:human genes:m:mrpl51|MRPL51]]|0.412|
|[[:human genes:c:cox10|COX10]]|0.412|
|[[:human genes:c:cycs|CYCS]]|0.412|
|[[:human genes:m:mrps35|MRPS35]]|0.411|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.409|
|[[:human genes:w:wars2|WARS2]]|0.408|
|[[:human genes:d:dohh|DOHH]]|0.406|
|[[:human genes:c:cox7c|COX7C]]|0.406|
|[[:human genes:m:mrps33|MRPS33]]|0.405|
|[[:human genes:p:pet112|PET112]]|0.404|
|[[:human genes:d:dhrsx|DHRSX]]|0.404|
|[[:human genes:m:mrpl42|MRPL42]]|0.404|
|[[:human genes:f:fastkd1|FASTKD1]]|0.403|
|[[:human genes:c:chchd4|CHCHD4]]|0.403|
|[[:human genes:p:ppa2|PPA2]]|0.401|
|[[:human genes:m:mrpl39|MRPL39]]|0.401|
|[[:human genes:a:atp5l|ATP5L]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|1/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|1/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1643
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COX7B Expression in NALM6 Cells: 6.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>