CPSF2 [The Human Chemical-Genetic Interaction Map Project]

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======= CPSF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CPSF2
  * **<color #00a2e8>Official Name</color>**: cleavage and polyadenylation specific factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=53981|53981]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P2I0|Q9P2I0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CPSF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CPSF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606028|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing. {ECO:0000269|PubMed:14749727, ECO:0000269|PubMed:18688255}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RMMBL|
|Beta-Casp|
|Lactamase B|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mRNA 3-end processing by stem-loop binding and cleavage|
|mRNA cleavage and polyadenylation specificity factor complex|
|mRNA cleavage|
|mRNA polyadenylation|
|histone mRNA metabolic process|
|RNA polyadenylation|
|termination of RNA polymerase II transcription|
|DNA-templated transcription, termination|
|mRNA 3-end processing|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|mRNA export from nucleus|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|RNA 3-end processing|
|protein export from nucleus|
|mRNA transport|
|nuclear export|
|RNA phosphodiester bond hydrolysis|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|RNA localization|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|nucleic acid phosphodiester bond hydrolysis|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|mRNA processing|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|RNA processing|
|intracellular protein transport|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|RNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2.44|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-2.09|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.84|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.83|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.8|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-1.8|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-1.73|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.74|
|[[:results:exp340|BN82002 4μM R07 exp340]]|1.76|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.78|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.84|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|1.95|
|[[:results:exp392|PT-1 25μM R07 exp392]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 630/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|20/28|
|blood|28/28|
|bone|22/25|
|breast|28/33|
|central nervous system|48/56|
|cervix|4/4|
|colorectal|15/17|
|esophagus|10/13|
|fibroblast|1/1|
|gastric|12/15|
|kidney|19/21|
|liver|17/20|
|lung|59/75|
|lymphocyte|12/14|
|ovary|22/26|
|pancreas|22/24|
|peripheral nervous system|16/16|
|plasma cell|12/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|18/22|
|urinary tract|27/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 647
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CPSF2 Expression in NALM6 Cells: 7.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>