CPSF6 [The Human Chemical-Genetic Interaction Map Project]

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======= CPSF6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CPSF6
  * **<color #00a2e8>Official Name</color>**: cleavage and polyadenylation specific factor 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11052|11052]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16630|Q16630]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CPSF6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CPSF6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604979|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing. Involved in association with NUDT21/CPSF5 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. CPSF6 binds to cleavage and polyadenylation RNA substrates and promotes RNA looping. {ECO:0000269|PubMed:14690600, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:21295486, ECO:0000269|PubMed:8626397, ECO:0000269|PubMed:9659921}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|exon-exon junction complex binding|
|messenger ribonucleoprotein complex assembly|
|mRNA alternative polyadenylation|
|perichromatin fibrils|
|interchromatin granule|
|mRNA cleavage factor complex|
|paraspeckles|
|positive regulation of RNA export from nucleus|
|positive regulation of nucleobase-containing compound transport|
|pre-mRNA cleavage required for polyadenylation|
|ribosomal large subunit binding|
|mRNA cleavage involved in mRNA processing|
|regulation of RNA export from nucleus|
|regulation of nucleobase-containing compound transport|
|mRNA cleavage and polyadenylation specificity factor complex|
|regulation of mRNA polyadenylation|
|mRNA cleavage|
|regulation of mRNA 3-end processing|
|protein heterotetramerization|
|positive regulation of nucleocytoplasmic transport|
|mRNA 3-end processing|
|regulation of nucleocytoplasmic transport|
|protein heterooligomerization|
|RNA 3-end processing|
|regulation of mRNA processing|
|protein tetramerization|
|ribonucleoprotein complex|
|RNA phosphodiester bond hydrolysis|
|mRNA binding|
|positive regulation of intracellular transport|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|nucleic acid phosphodiester bond hydrolysis|
|regulation of mRNA metabolic process|
|regulation of intracellular transport|
|nuclear speck|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|protein complex oligomerization|
|mRNA metabolic process|
|cellular protein-containing complex assembly|
|RNA processing|
|regulation of cellular localization|
|positive regulation of transport|
|RNA binding|
|protein-containing complex assembly|
|RNA metabolic process|
|protein-containing complex subunit organization|
|regulation of transport|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-2.46|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.81|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.78|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|1.81|
|[[:results:exp124|GSK343 3μM R03 exp124]]|1.95|
|[[:results:exp358|FK-506 5μM R07 exp358]]|1.98|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 182/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|7/28|
|blood|9/28|
|bone|5/26|
|breast|12/33|
|central nervous system|16/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|7/16|
|kidney|2/21|
|liver|5/20|
|lung|19/75|
|lymphocyte|6/16|
|ovary|9/26|
|pancreas|7/24|
|peripheral nervous system|1/16|
|plasma cell|3/15|
|prostate|1/1|
|skin|5/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|7/22|
|urinary tract|7/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1311
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CPSF6 Expression in NALM6 Cells: 8.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>