CPT1A [The Human Chemical-Genetic Interaction Map Project]

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======= CPT1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CPT1A
  * **<color #00a2e8>Official Name</color>**: carnitine palmitoyltransferase 1A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1374|1374]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P50416|P50416]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CPT1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CPT1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600528|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Plays an important role in triglyceride metabolism.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Carn acyltransf|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|palmitoleoyltransferase activity|
|carnitine O-palmitoyltransferase activity|
|positive regulation of fatty acid beta-oxidation|
|carnitine shuttle|
|carnitine metabolic process|
|fatty acid transmembrane transport|
|positive regulation of fatty acid oxidation|
|amino-acid betaine metabolic process|
|regulation of fatty acid beta-oxidation|
|integral component of mitochondrial outer membrane|
|positive regulation of lipid catabolic process|
|eating behavior|
|regulation of fatty acid oxidation|
|positive regulation of fatty acid metabolic process|
|intracellular lipid transport|
|regulation of lipid catabolic process|
|cellular response to fatty acid|
|fatty acid beta-oxidation|
|long-chain fatty acid transport|
|fatty acid transport|
|triglyceride metabolic process|
|fatty acid oxidation|
|lipid oxidation|
|response to fatty acid|
|feeding behavior|
|regulation of fatty acid metabolic process|
|mitochondrial transmembrane transport|
|fatty acid catabolic process|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|glucose metabolic process|
|long-chain fatty acid metabolic process|
|monocarboxylic acid catabolic process|
|organic acid transmembrane transport|
|carboxylic acid transmembrane transport|
|monocarboxylic acid transport|
|positive regulation of small molecule metabolic process|
|circadian rhythm|
|positive regulation of lipid metabolic process|
|hexose metabolic process|
|mitochondrial outer membrane|
|regulation of cellular ketone metabolic process|
|regulation of insulin secretion|
|ammonium ion metabolic process|
|cellular lipid catabolic process|
|cellular modified amino acid metabolic process|
|monosaccharide metabolic process|
|lipid modification|
|cellular response to acid chemical|
|regulation of peptide hormone secretion|
|mitochondrial transport|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|regulation of hormone secretion|
|rhythmic process|
|anion transmembrane transport|
|carboxylic acid transport|
|organic acid transport|
|lipid transport|
|lipid catabolic process|
|lipid localization|
|fatty acid metabolic process|
|protein homooligomerization|
|response to acid chemical|
|positive regulation of cellular catabolic process|
|glycerolipid metabolic process|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|positive regulation of catabolic process|
|small molecule catabolic process|
|organic anion transport|
|regulation of protein secretion|
|carbohydrate metabolic process|
|regulation of peptide secretion|
|protein complex oligomerization|
|cellular response to lipid|
|monocarboxylic acid metabolic process|
|regulation of hormone levels|
|behavior|
|anion transport|
|epithelial cell differentiation|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|regulation of cellular catabolic process|
|response to lipid|
|carboxylic acid metabolic process|
|response to organic cyclic compound|
|ion transmembrane transport|
|cellular lipid metabolic process|
|oxidation-reduction process|
|regulation of catabolic process|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|identical protein binding|
|epithelium development|
|lipid metabolic process|
|mitochondrion|
|transmembrane transport|
|ion transport|
|intracellular transport|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|small molecule metabolic process|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8391
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.82 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CPT1A Expression in NALM6 Cells: 6.82'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>