CRABP2 [The Human Chemical-Genetic Interaction Map Project]

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======= CRABP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CRABP2
  * **<color #00a2e8>Official Name</color>**: cellular retinoic acid binding protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1382|1382]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P29373|P29373]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CRABP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CRABP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/180231|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lipocalin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|retinoid binding|
|retinoic acid biosynthetic process|
|diterpenoid biosynthetic process|
|retinal binding|
|positive regulation of collateral sprouting|
|retinol binding|
|terpenoid biosynthetic process|
|regulation of retinoic acid receptor signaling pathway|
|regulation of collateral sprouting|
|retinoic acid binding|
|isoprenoid biosynthetic process|
|retinoic acid metabolic process|
|embryonic forelimb morphogenesis|
|forelimb morphogenesis|
|positive regulation of axonogenesis|
|retinoid metabolic process|
|diterpenoid metabolic process|
|regulation of extent of cell growth|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|embryonic limb morphogenesis|
|embryonic appendage morphogenesis|
|isoprenoid metabolic process|
|limb morphogenesis|
|appendage morphogenesis|
|positive regulation of cell morphogenesis involved in differentiation|
|positive regulation of cell growth|
|positive regulation of developmental growth|
|appendage development|
|limb development|
|regulation of cell size|
|regulation of axonogenesis|
|monocarboxylic acid biosynthetic process|
|hormone metabolic process|
|positive regulation of growth|
|positive regulation of neuron projection development|
|carboxylic acid biosynthetic process|
|regulation of cell morphogenesis involved in differentiation|
|organic acid biosynthetic process|
|regulation of developmental growth|
|positive regulation of neuron differentiation|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|epidermis development|
|regulation of cell growth|
|positive regulation of neurogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|regulation of anatomical structure size|
|monocarboxylic acid metabolic process|
|regulation of hormone levels|
|positive regulation of nervous system development|
|positive regulation of cell development|
|embryonic morphogenesis|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|regulation of neuron differentiation|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of neurogenesis|
|carboxylic acid metabolic process|
|regulation of nervous system development|
|regulation of cell development|
|cellular lipid metabolic process|
|positive regulation of cell differentiation|
|embryo development|
|oxoacid metabolic process|
|endoplasmic reticulum|
|organic acid metabolic process|
|regulation of anatomical structure morphogenesis|
|positive regulation of cellular component organization|
|lipid metabolic process|
|positive regulation of developmental process|
|generation of neurons|
|neurogenesis|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|tissue development|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-1.81|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-1.77|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|1.71|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|1.77|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.91|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|1.92|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|1.95|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6943
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CRABP2 Expression in NALM6 Cells: 0.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>