CRB2 [The Human Chemical-Genetic Interaction Map Project]

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======= CRB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CRB2
  * **<color #00a2e8>Official Name</color>**: crumbs cell polarity complex component 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=286204|286204]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5IJ48|Q5IJ48]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CRB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CRB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609720|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of a family of proteins that are components of the Crumbs cell polarity complex. In mammals, members of this family are thought to play a role in many cellular processes in early embryonic development. A similar protein in Drosophila determines apicobasal polarity in embryonic epithelial cells. Mutations in this gene are associated with focal segmental glomerulosclerosis 9, and with ventriculomegaly with cystic kidney disease. [provided by RefSeq, Aug 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Apical polarity protein that plays a central role during the epithelial-to-mesenchymal transition (EMT) at gastrulation, when newly specified mesodermal cells move inside the embryo. Acts by promoting cell ingression, the process by which cells leave the epithelial epiblast and move inside the embryo to form a new tissue layer. The anisotropic distribution of CRB2 and MYH10/myosin-IIB at cell edges define which cells will ingress: cells with high apical CRB2 are probably extruded from the epiblast by neighboring cells with high levels of apical MYH10/myosin-IIB. Also required for maintenance of the apical polarity complex during development of the cortex. {ECO:0000250|UniProtKB:Q80YA8}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EGF|
|Laminin G 2|
|EGF CA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ingression involved in gastrulation with mouth forming second|
|aspartic-type endopeptidase inhibitor activity|
|notochord formation|
|notochord morphogenesis|
|maintenance of apical/basal cell polarity|
|maintenance of epithelial cell apical/basal polarity|
|cell migration involved in gastrulation|
|maintenance of cell polarity|
|notochord development|
|gastrulation with mouth forming second|
|positive regulation of BMP signaling pathway|
|regulation of gastrulation|
|establishment or maintenance of epithelial cell apical/basal polarity|
|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|
|positive regulation of epithelial to mesenchymal transition|
|establishment or maintenance of bipolar cell polarity|
|establishment or maintenance of apical/basal cell polarity|
|somitogenesis|
|mesoderm formation|
|mesoderm morphogenesis|
|somite development|
|regulation of epithelial to mesenchymal transition|
|regulation of BMP signaling pathway|
|segmentation|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|formation of primary germ layer|
|mesoderm development|
|regulation of embryonic development|
|gastrulation|
|ameboidal-type cell migration|
|establishment or maintenance of cell polarity|
|anterior/posterior pattern specification|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|protein-containing complex binding|
|regulation of cellular response to growth factor stimulus|
|embryonic organ morphogenesis|
|apical plasma membrane|
|regionalization|
|negative regulation of proteolysis|
|regulation of endopeptidase activity|
|embryonic organ development|
|pattern specification process|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|cell-cell adhesion|
|cardiovascular system development|
|tissue morphogenesis|
|embryonic morphogenesis|
|protein-containing complex|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|calcium ion binding|
|regulation of proteolysis|
|negative regulation of catalytic activity|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|negative regulation of cellular protein metabolic process|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|negative regulation of protein metabolic process|
|epithelium development|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|locomotion|
|positive regulation of developmental process|
|movement of cell or subcellular component|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7713
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CRB2 Expression in NALM6 Cells: 1.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>