CRHR1 [The Human Chemical-Genetic Interaction Map Project]

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======= CRHR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CRHR1
  * **<color #00a2e8>Official Name</color>**: corticotropin releasing hormone receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1394|1394]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P34998|P34998]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CRHR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CRHR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/122561|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Naturally-occurring readthrough transcription between this gene and upstream GeneID:147081 results in transcripts that encode isoforms that share similarity with the products of this gene. [provided by RefSeq, Aug 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  G-protein coupled receptor for CRH (corticotropin- releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. {ECO:0000269|PubMed:18292205, ECO:0000269|PubMed:18801728, ECO:0000269|PubMed:23576434, ECO:0000269|PubMed:23863939}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HRM|
|7tm 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|corticotropin secretion|
|regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway|
|general adaptation syndrome, behavioral process|
|corticotrophin-releasing factor receptor activity|
|corticotropin-releasing hormone receptor activity|
|corticotropin-releasing hormone binding|
|general adaptation syndrome|
|regulation of corticosterone secretion|
|cellular response to corticotropin-releasing hormone stimulus|
|response to corticotropin-releasing hormone|
|negative regulation of epinephrine secretion|
|regulation of epinephrine secretion|
|regulation of glucocorticoid secretion|
|negative regulation of feeding behavior|
|behavioral response to ethanol|
|endocrine hormone secretion|
|locomotory exploration behavior|
|negative regulation of voltage-gated calcium channel activity|
|behavioral response to pain|
|positive regulation of mast cell activation involved in immune response|
|negative regulation of catecholamine secretion|
|positive regulation of mast cell degranulation|
|regulation of corticosteroid hormone secretion|
|parturition|
|negative regulation of behavior|
|regulation of steroid hormone secretion|
|positive regulation of mast cell activation|
|behavioral response to cocaine|
|hypothalamus development|
|positive regulation of cAMP-mediated signaling|
|G-protein alpha-subunit binding|
|positive regulation of leukocyte degranulation|
|adrenal gland development|
|negative regulation of amine transport|
|exploration behavior|
|response to immobilization stress|
|regulation of adenylate cyclase activity|
|regulation of feeding behavior|
|response to pain|
|positive regulation of myeloid leukocyte mediated immunity|
|multivesicular body|
|fear response|
|regulation of mast cell degranulation|
|regulation of mast cell activation involved in immune response|
|negative regulation of calcium ion transmembrane transporter activity|
|regulation of voltage-gated calcium channel activity|
|intrinsic component of plasma membrane|
|activation of adenylate cyclase activity|
|negative regulation of calcium ion transmembrane transport|
|peptide hormone binding|
|response to electrical stimulus|
|regulation of cyclase activity|
|negative regulation of cation channel activity|
|regulation of endocrine process|
|regulation of lyase activity|
|regulation of mast cell activation|
|long-term synaptic potentiation|
|visual learning|
|endocrine process|
|regulation of leukocyte degranulation|
|regulation of cAMP-mediated signaling|
|positive regulation of regulated secretory pathway|
|visual behavior|
|response to cocaine|
|regulation of myeloid leukocyte mediated immunity|
|peptide hormone secretion|
|negative regulation of calcium ion transport|
|regulation of catecholamine secretion|
|multicellular organismal response to stress|
|negative regulation of ion transmembrane transporter activity|
|apical part of cell|
|regulation of behavior|
|hormone secretion|
|diencephalon development|
|response to anesthetic|
|associative learning|
|negative regulation of transporter activity|
|hormone transport|
|negative regulation of cation transmembrane transport|
|feeding behavior|
|regulation of calcium ion transmembrane transporter activity|
|positive regulation of exocytosis|
|regulation of amine transport|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|negative regulation of ion transmembrane transport|
|neuropeptide signaling pathway|
|regulation of lipid transport|
|limbic system development|
|response to alkaloid|
|negative regulation of transmembrane transport|
|memory|
|endocrine system development|
|response to ethanol|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|positive regulation of leukocyte mediated immunity|
|regulation of lipid localization|
|adult behavior|
|learning|
|negative regulation of ion transport|
|cAMP-mediated signaling|
|regulation of calcium ion transmembrane transport|
|positive regulation of synaptic transmission|
|regulation of regulated secretory pathway|
|signal release|
|trans-Golgi network|
|hormone-mediated signaling pathway|
|regulation of cation channel activity|
|cyclic-nucleotide-mediated signaling|
|peptide secretion|
|female pregnancy|
|response to ammonium ion|
|regulation of synaptic plasticity|
|locomotory behavior|
|negative regulation of secretion by cell|
|regulation of leukocyte mediated immunity|
|negative regulation of neuron death|
|positive regulation of intracellular transport|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|multi-multicellular organism process|
|positive regulation of immune effector process|
|regulation of exocytosis|
|negative regulation of secretion|
|response to alcohol|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|regulation of calcium ion transport|
|regulation of ion transmembrane transporter activity|
|learning or memory|
|regulation of transmembrane transporter activity|
|protein-containing complex binding|
|cellular response to peptide hormone stimulus|
|regulation of hormone secretion|
|regulation of transporter activity|
|positive regulation of cytosolic calcium ion concentration|
|cognition|
|response to xenobiotic stimulus|
|response to antibiotic|
|response to light stimulus|
|regulation of neuron death|
|cellular response to peptide|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|second-messenger-mediated signaling|
|response to hypoxia|
|regulation of intracellular transport|
|response to decreased oxygen levels|
|neuronal cell body|
|response to oxygen levels|
|forebrain development|
|regulation of metal ion transport|
|response to peptide hormone|
|positive regulation of secretion by cell|
|positive regulation of leukocyte activation|
|gland development|
|positive regulation of cell activation|
|dendrite|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|response to radiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|regulation of immune effector process|
|response to peptide|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|response to toxic substance|
|regulation of hormone levels|
|regulation of vesicle-mediated transport|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|behavior|
|regulation of system process|
|cellular response to organonitrogen compound|
|regulation of leukocyte activation|
|cellular response to hormone stimulus|
|metal ion homeostasis|
|cellular cation homeostasis|
|regulation of cell activation|
|cellular ion homeostasis|
|cellular response to nitrogen compound|
|epithelial cell differentiation|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|brain development|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|head development|
|ion homeostasis|
|regulation of secretion|
|positive regulation of immune response|
|cellular homeostasis|
|response to hormone|
|regulation of cellular localization|
|response to organic cyclic compound|
|central nervous system development|
|positive regulation of transport|
|multi-organism reproductive process|
|negative regulation of cell death|
|response to organonitrogen compound|
|secretion by cell|
|positive regulation of intracellular signal transduction|
|response to drug|
|export from cell|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|epithelium development|
|cell-cell signaling|
|secretion|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|G protein-coupled receptor signaling pathway|
|nervous system process|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|nitrogen compound transport|
|regulation of transport|
|immune response|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|-1.82|
|[[:results:exp219|A-395N 10μM R05 exp219]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5225
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CRHR1 Expression in NALM6 Cells: -5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>