CRNKL1 [The Human Chemical-Genetic Interaction Map Project]

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======= CRNKL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CRNKL1
  * **<color #00a2e8>Official Name</color>**: crooked neck pre-mRNA splicing factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51340|51340]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BZJ0|Q9BZJ0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CRNKL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CRNKL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610952|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HAT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|post-mRNA release spliceosomal complex|
|Prp19 complex|
|U2-type catalytic step 2 spliceosome|
|spliceosomal complex assembly|
|catalytic step 2 spliceosome|
|spliceosomal complex|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|nuclear speck|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|mRNA metabolic process|
|cellular protein-containing complex assembly|
|RNA processing|
|RNA binding|
|protein-containing complex assembly|
|RNA metabolic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.95|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.83|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.77|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|1.71|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|1.72|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.73|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|1.75|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|1.79|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|1.79|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.79|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|1.81|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|1.82|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|1.84|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.84|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|1.9|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|1.91|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|1.96|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|1.97|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.07|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|2.13|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|2.16|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|2.25|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.5|
|[[:human genes:n:napa|NAPA]]|0.485|
|[[:human genes:w:wdr87|WDR87]]|0.475|
|[[:human genes:d:dtl|DTL]]|0.46|
|[[:human genes:n:npipb5|NPIPB5]]|0.453|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.443|
|[[:human genes:t:tceb3c|TCEB3C]]|0.443|
|[[:human genes:c:cln6|CLN6]]|0.44|
|[[:human genes:c:copg1|COPG1]]|0.438|
|[[:human genes:c:cdc73|CDC73]]|0.438|
|[[:human genes:m:myt1l|MYT1L]]|0.436|
|[[:human genes:c:ccna2|CCNA2]]|0.432|
|[[:human genes:s:supt5h|SUPT5H]]|0.43|
|[[:human genes:s:slc6a17|SLC6A17]]|0.429|
|[[:human genes:d:dock6|DOCK6]]|0.426|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.422|
|[[:human genes:v:vasn|VASN]]|0.416|
|[[:human genes:n:nufip2|NUFIP2]]|0.413|
|[[:human genes:c:chd4|CHD4]]|0.412|
|[[:human genes:i:iscu|ISCU]]|0.411|
|[[:human genes:o:orc6|ORC6]]|0.41|
|[[:human genes:c:cdca5|CDCA5]]|0.41|
|[[:human genes:c:col2a1|COL2A1]]|0.409|
|[[:human genes:m:myo1h|MYO1H]]|0.408|
|[[:human genes:o:orc1|ORC1]]|0.408|
|[[:human genes:k:kctd17|KCTD17]]|0.404|
|[[:human genes:t:tsg101|TSG101]]|0.402|
|[[:human genes:m:madcam1|MADCAM1]]|0.4|
|[[:human genes:p:psmb2|PSMB2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 679/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|26/28|
|blood|28/28|
|bone|23/26|
|breast|32/33|
|central nervous system|48/56|
|cervix|3/4|
|colorectal|14/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|14/16|
|kidney|19/21|
|liver|19/20|
|lung|69/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|23/24|
|peripheral nervous system|14/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|19/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|19/22|
|urinary tract|24/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1611
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CRNKL1 Expression in NALM6 Cells: 5.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>