CRTC1 [The Human Chemical-Genetic Interaction Map Project]

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======= CRTC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CRTC1
  * **<color #00a2e8>Official Name</color>**: CREB regulated transcription coactivator 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23373|23373]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6UUV9|Q6UUV9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CRTC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CRTC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607536|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long- term potentiation (L-LTP) maintenance at the Schaffer collateral- CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. {ECO:0000250|UniProtKB:Q157S1, ECO:0000250|UniProtKB:Q68ED7, ECO:0000269|PubMed:23699513}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TORC N|
|TORC C|
|TORC M|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of membrane hyperpolarization|
|regulation of membrane hyperpolarization|
|cAMP response element binding protein binding|
|postsynapse to nucleus signaling pathway|
|positive regulation of CREB transcription factor activity|
|entrainment of circadian clock by photoperiod|
|positive regulation of long-term synaptic potentiation|
|photoperiodism|
|entrainment of circadian clock|
|energy homeostasis|
|postsynaptic signal transduction|
|regulation of long-term synaptic potentiation|
|positive regulation of dendrite development|
|protein homotetramerization|
|regulation of circadian rhythm|
|memory|
|regulation of dendrite development|
|protein tetramerization|
|positive regulation of synaptic transmission|
|regulation of synaptic plasticity|
|postsynaptic density|
|learning or memory|
|positive regulation of DNA-binding transcription factor activity|
|rhythmic process|
|positive regulation of neuron projection development|
|nuclear body|
|cognition|
|response to light stimulus|
|multicellular organismal homeostasis|
|protein homooligomerization|
|glutamatergic synapse|
|positive regulation of neuron differentiation|
|neuronal cell body|
|positive regulation of cell projection organization|
|dendrite|
|regulation of DNA-binding transcription factor activity|
|regulation of membrane potential|
|response to radiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|positive regulation of neurogenesis|
|regulation of neuron projection development|
|protein complex oligomerization|
|positive regulation of nervous system development|
|positive regulation of cell development|
|behavior|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|viral process|
|regulation of cell projection organization|
|symbiotic process|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|cell-cell signaling|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of developmental process|
|nervous system process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|protein-containing complex assembly|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp518|RK-33 8μM R08 exp518]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4674
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CRTC1 Expression in NALM6 Cells: 4.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>