CSF1 [The Human Chemical-Genetic Interaction Map Project]

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======= CSF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CSF1
  * **<color #00a2e8>Official Name</color>**: colony stimulating factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1435|1435]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09603|P09603]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CSF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CSF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/120420|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. {ECO:0000269|PubMed:16337366, ECO:0000269|PubMed:19934330, ECO:0000269|PubMed:20504948, ECO:0000269|PubMed:20829061}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CSF-1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of macrophage colony-stimulating factor signaling pathway|
|mammary gland fat development|
|CSF1-CSF1R complex|
|mammary duct terminal end bud growth|
|positive regulation of cellular response to macrophage colony-stimulating factor stimulus|
|macrophage colony-stimulating factor receptor binding|
|regulation of macrophage colony-stimulating factor signaling pathway|
|positive regulation of response to macrophage colony-stimulating factor|
|macrophage colony-stimulating factor signaling pathway|
|osteoclast proliferation|
|positive regulation of odontogenesis of dentin-containing tooth|
|positive regulation of microglial cell migration|
|regulation of cellular response to macrophage colony-stimulating factor stimulus|
|regulation of response to macrophage colony-stimulating factor|
|macrophage proliferation|
|regulation of microglial cell migration|
|microglial cell proliferation|
|cellular response to macrophage colony-stimulating factor stimulus|
|response to macrophage colony-stimulating factor|
|positive regulation of glial cell migration|
|monocyte activation|
|positive regulation of monocyte differentiation|
|positive regulation of odontogenesis|
|regulation of odontogenesis of dentin-containing tooth|
|positive regulation of macrophage differentiation|
|positive regulation of macrophage chemotaxis|
|regulation of glial cell migration|
|positive regulation of macrophage derived foam cell differentiation|
|glial cell proliferation|
|regulation of monocyte differentiation|
|positive regulation of macrophage migration|
|regulation of macrophage differentiation|
|branching involved in mammary gland duct morphogenesis|
|macrophage differentiation|
|positive regulation of osteoclast differentiation|
|regulation of macrophage chemotaxis|
|regulation of odontogenesis|
|regulation of macrophage derived foam cell differentiation|
|homeostasis of number of cells within a tissue|
|mammary gland duct morphogenesis|
|positive regulation of multicellular organism growth|
|adipose tissue development|
|regulation of macrophage migration|
|regulation of granulocyte chemotaxis|
|mammary gland morphogenesis|
|osteoclast differentiation|
|regulation of mononuclear cell migration|
|response to ischemia|
|positive regulation of cytokine-mediated signaling pathway|
|positive regulation of cell-matrix adhesion|
|positive regulation of myeloid leukocyte differentiation|
|positive regulation of response to cytokine stimulus|
|mammary gland epithelium development|
|positive regulation of Ras protein signal transduction|
|regulation of osteoclast differentiation|
|regulation of multicellular organism growth|
|positive regulation of gliogenesis|
|positive regulation of small GTPase mediated signal transduction|
|positive regulation of animal organ morphogenesis|
|positive regulation of leukocyte chemotaxis|
|positive regulation of myeloid cell differentiation|
|leukocyte proliferation|
|gland morphogenesis|
|myeloid leukocyte differentiation|
|regulation of leukocyte chemotaxis|
|regulation of cell-matrix adhesion|
|developmental growth involved in morphogenesis|
|regulation of gliogenesis|
|regulation of myeloid leukocyte differentiation|
|positive regulation of cell-substrate adhesion|
|mammary gland development|
|positive regulation of leukocyte migration|
|branching morphogenesis of an epithelial tube|
|positive regulation of mononuclear cell proliferation|
|positive regulation of chemotaxis|
|positive regulation of leukocyte proliferation|
|positive regulation of leukocyte differentiation|
|morphogenesis of a branching epithelium|
|growth factor activity|
|regulation of cytokine-mediated signaling pathway|
|morphogenesis of a branching structure|
|positive regulation of developmental growth|
|cytokine activity|
|regulation of response to cytokine stimulus|
|positive regulation of hemopoiesis|
|regulation of ossification|
|tissue homeostasis|
|regulation of leukocyte migration|
|homeostasis of number of cells|
|negative regulation of neuron death|
|regulation of mononuclear cell proliferation|
|regulation of cell-substrate adhesion|
|regulation of chemotaxis|
|gliogenesis|
|myeloid cell differentiation|
|regulation of leukocyte proliferation|
|connective tissue development|
|regulation of myeloid cell differentiation|
|regulation of Ras protein signal transduction|
|regulation of animal organ morphogenesis|
|positive regulation of growth|
|regulation of leukocyte differentiation|
|endoplasmic reticulum lumen|
|epithelial tube morphogenesis|
|regulation of neuron death|
|multicellular organismal homeostasis|
|regulation of developmental growth|
|leukocyte differentiation|
|anatomical structure homeostasis|
|regulation of small GTPase mediated signal transduction|
|post-translational protein modification|
|developmental growth|
|growth|
|positive regulation of cell adhesion|
|gland development|
|morphogenesis of an epithelium|
|regulation of hemopoiesis|
|positive regulation of neurogenesis|
|inflammatory response|
|positive regulation of cell migration|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|positive regulation of cell motility|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|positive regulation of locomotion|
|cell population proliferation|
|hemopoiesis|
|tissue morphogenesis|
|positive regulation of kinase activity|
|myeloid leukocyte activation|
|positive regulation of response to external stimulus|
|hematopoietic or lymphoid organ development|
|immune system development|
|tube morphogenesis|
|positive regulation of transferase activity|
|developmental process involved in reproduction|
|regulation of growth|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|perinuclear region of cytoplasm|
|enzyme linked receptor protein signaling pathway|
|innate immune response|
|regulation of protein kinase activity|
|regulation of neurogenesis|
|tube development|
|regulation of cell migration|
|regulation of kinase activity|
|protein homodimerization activity|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|defense response to other organism|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|regulation of locomotion|
|negative regulation of cell death|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|cell activation|
|regulation of response to external stimulus|
|response to cytokine|
|epithelium development|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of immune system process|
|positive regulation of protein modification process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|generation of neurons|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|extracellular region|
|positive regulation of gene expression|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.528|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6577
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.82 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CSF1 Expression in NALM6 Cells: -0.82'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>