CTBP1 [The Human Chemical-Genetic Interaction Map Project]

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======= CTBP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CTBP1
  * **<color #00a2e8>Official Name</color>**: C-terminal binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1487|1487]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13363|Q13363]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CTBP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CTBP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602618|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. {ECO:0000269|PubMed:12419229, ECO:0000269|PubMed:15542832, ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:9858600}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|2-Hacid dh|
|2-Hacid dh C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of histone H4 acetylation|
|white fat cell differentiation|
|regulation of histone H4 acetylation|
|presynaptic active zone cytoplasmic component|
|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|
|negative regulation of histone acetylation|
|positive regulation of histone deacetylation|
|negative regulation of peptidyl-lysine acetylation|
|negative regulation of protein acetylation|
|positive regulation of protein deacetylation|
|viral genome replication|
|regulation of histone deacetylation|
|repressing transcription factor binding|
|NAD binding|
|negative regulation of histone modification|
|regulation of protein deacetylation|
|regulation of histone acetylation|
|transcriptional repressor complex|
|chromatin organization involved in negative regulation of transcription|
|chromatin silencing|
|negative regulation of chromatin organization|
|regulation of peptidyl-lysine acetylation|
|GABA-ergic synapse|
|chromatin organization involved in regulation of transcription|
|regulation of protein acetylation|
|negative regulation of gene expression, epigenetic|
|positive regulation of histone modification|
|positive regulation of chromatin organization|
|fat cell differentiation|
|negative regulation of chromosome organization|
|regulation of histone modification|
|gene silencing|
|positive regulation of chromosome organization|
|protein C-terminus binding|
|regulation of chromatin organization|
|viral life cycle|
|transcription factor complex|
|regulation of gene expression, epigenetic|
|transcription corepressor activity|
|protein domain specific binding|
|transcription factor binding|
|glutamatergic synapse|
|regulation of chromosome organization|
|negative regulation of organelle organization|
|negative regulation of protein modification process|
|positive regulation of organelle organization|
|DNA-binding transcription factor activity|
|negative regulation of cell population proliferation|
|chromatin organization|
|viral process|
|negative regulation of cellular component organization|
|symbiotic process|
|interspecies interaction between organisms|
|negative regulation of transcription by RNA polymerase II|
|oxidation-reduction process|
|protein phosphorylation|
|negative regulation of cellular protein metabolic process|
|chromosome organization|
|identical protein binding|
|negative regulation of protein metabolic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|phosphorylation|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.3|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.21|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-2|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.92|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-1.75|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.77|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.84|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|1.89|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|1.9|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18540
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CTBP1 Expression in NALM6 Cells: 7.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>