CTC1 [The Human Chemical-Genetic Interaction Map Project]

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======= CTC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CTC1
  * **<color #00a2e8>Official Name</color>**: CST telomere replication complex component 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80169|80169]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q2NKJ3|Q2NKJ3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CTC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CTC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613129|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a component of the CST complex. This complex plays an essential role in protecting telomeres from degradation. This protein also forms a heterodimer with the CST complex subunit STN1 to form the enzyme alpha accessory factor. This enzyme regulates DNA replication. Mutations in this gene are the cause of cerebroretinal microangiopathy with calcifications and cysts. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha (PubMed:22763445). The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins (PubMed:25483097). Involved in telomere maintenance (PubMed:19854131, PubMed:22863775). Involved in genome stability (PubMed:22863775). May be in involved in telomeric C-strand fill- in during late S/G2 phase (By similarity). {ECO:0000250|UniProtKB:Q5SUQ9, ECO:0000269|PubMed:19854130, ECO:0000269|PubMed:19854131, ECO:0000269|PubMed:22763445, ECO:0000269|PubMed:22863775, ECO:0000269|PubMed:25483097}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CST complex|
|G-rich strand telomeric DNA binding|
|telomere capping|
|negative regulation of telomere maintenance via telomerase|
|negative regulation of telomere maintenance via telomere lengthening|
|telomeric DNA binding|
|telomere maintenance via telomere lengthening|
|positive regulation of DNA replication|
|negative regulation of telomere maintenance|
|negative regulation of DNA biosynthetic process|
|regulation of telomere maintenance via telomerase|
|regulation of telomere maintenance via telomere lengthening|
|regulation of telomere maintenance|
|telomere maintenance|
|telomere organization|
|single-stranded DNA binding|
|regulation of DNA replication|
|nuclear chromosome, telomeric region|
|regulation of DNA biosynthetic process|
|negative regulation of DNA metabolic process|
|negative regulation of chromosome organization|
|anatomical structure homeostasis|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|negative regulation of organelle organization|
|negative regulation of cellular component organization|
|DNA metabolic process|
|chromosome organization|
|regulation of organelle organization|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|homeostatic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp116|AICAR 240μM R03 exp116]]|-2.27|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-2.27|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|-2.2|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-2.2|
|[[:results:exp331|A-769662 20μM R07 exp331]]|-2.19|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.16|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-2.12|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|-2.09|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-2.09|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-2.06|
|[[:results:exp218|A-395 10μM R05 exp218]]|-2.05|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-2.05|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-2.04|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|-2.03|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-2.03|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-2.01|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-2|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-1.98|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.94|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.93|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.93|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-1.92|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-1.84|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.84|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-1.83|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|-1.83|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-1.81|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-1.8|
|[[:results:exp16|DABN 2μM R00 exp16]]|-1.75|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:ten1|TEN1]]|0.64|
|[[:human genes:h:hars|HARS]]|0.544|
|[[:human genes:g:gemin8|GEMIN8]]|0.538|
|[[:human genes:r:rtcb|RTCB]]|0.515|
|[[:human genes:t:thg1l|THG1L]]|0.505|
|[[:human genes:c:c15orf41|C15orf41]]|0.493|
|[[:human genes:u:uap1|UAP1]]|0.489|
|[[:human genes:r:rpp21|RPP21]]|0.488|
|[[:human genes:u:uhrf1|UHRF1]]|0.486|
|[[:human genes:o:obfc1|OBFC1]]|0.477|
|[[:human genes:d:ddx55|DDX55]]|0.469|
|[[:human genes:v:vezt|VEZT]]|0.468|
|[[:human genes:g:gemin7|GEMIN7]]|0.46|
|[[:human genes:g:gemin6|GEMIN6]]|0.458|
|[[:human genes:r:rpia|RPIA]]|0.456|
|[[:human genes:t:tsen54|TSEN54]]|0.455|
|[[:human genes:t:tbcb|TBCB]]|0.454|
|[[:human genes:a:alg1|ALG1]]|0.452|
|[[:human genes:s:srp14|SRP14]]|0.451|
|[[:human genes:p:pmm2|PMM2]]|0.445|
|[[:human genes:a:atxn10|ATXN10]]|0.441|
|[[:human genes:r:rabggtb|RABGGTB]]|0.439|
|[[:human genes:p:ppp4c|PPP4C]]|0.435|
|[[:human genes:g:gmppb|GMPPB]]|0.433|
|[[:human genes:r:rft1|RFT1]]|0.433|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.433|
|[[:human genes:z:zrsr2|ZRSR2]]|0.432|
|[[:human genes:d:dpf2|DPF2]]|0.431|
|[[:human genes:r:rptor|RPTOR]]|0.429|
|[[:human genes:r:rpe|RPE]]|0.429|
|[[:human genes:u:utp23|UTP23]]|0.427|
|[[:human genes:d:dohh|DOHH]]|0.426|
|[[:human genes:f:fh|FH]]|0.425|
|[[:human genes:p:ppcs|PPCS]]|0.42|
|[[:human genes:n:nbn|NBN]]|0.414|
|[[:human genes:l:lsm10|LSM10]]|0.414|
|[[:human genes:n:nae1|NAE1]]|0.411|
|[[:human genes:d:dr1|DR1]]|0.411|
|[[:human genes:t:tbca|TBCA]]|0.41|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.407|
|[[:human genes:t:triap1|TRIAP1]]|0.406|
|[[:human genes:e:exoc4|EXOC4]]|0.406|
|[[:human genes:d:dhrsx|DHRSX]]|0.4|
|[[:human genes:t:trmt5|TRMT5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1176
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CTC1 Expression in NALM6 Cells: 5.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>