CTDSPL2 [The Human Chemical-Genetic Interaction Map Project]

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======= CTDSPL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CTDSPL2
  * **<color #00a2e8>Official Name</color>**: CTD small phosphatase like 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51496|51496]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q05D32|Q05D32]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CTDSPL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CTDSPL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618739|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable phosphatase. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NIF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of protein export from nucleus|
|regulation of protein export from nucleus|
|phosphoprotein phosphatase activity|
|negative regulation of BMP signaling pathway|
|positive regulation of nucleocytoplasmic transport|
|regulation of BMP signaling pathway|
|regulation of nucleocytoplasmic transport|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|negative regulation of cellular response to growth factor stimulus|
|positive regulation of intracellular protein transport|
|positive regulation of intracellular transport|
|protein dephosphorylation|
|regulation of intracellular protein transport|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of cellular response to growth factor stimulus|
|dephosphorylation|
|positive regulation of cellular protein localization|
|regulation of intracellular transport|
|positive regulation of protein transport|
|positive regulation of establishment of protein localization|
|regulation of cellular protein localization|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of cellular localization|
|positive regulation of transport|
|regulation of protein localization|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of response to stimulus|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-2.1|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-1.97|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.79|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.7|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.71|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.72|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.73|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|1.77|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.85|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.98|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|2.09|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:z:znf592|ZNF592]]|0.498|
|[[:human genes:m:med23|MED23]]|0.477|
|[[:human genes:m:maml1|MAML1]]|0.476|
|[[:human genes:t:trim33|TRIM33]]|0.452|
|[[:human genes:m:mef2c|MEF2C]]|0.441|
|[[:human genes:b:brpf1|BRPF1]]|0.439|
|[[:human genes:s:ssbp2|SSBP2]]|0.434|
|[[:human genes:t:tada1|TADA1]]|0.428|
|[[:human genes:m:med13l|MED13L]]|0.422|
|[[:human genes:t:taf5l|TAF5L]]|0.412|
|[[:human genes:t:tfap4|TFAP4]]|0.408|
|[[:human genes:a:asxl2|ASXL2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1442
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CTDSPL2 Expression in NALM6 Cells: 7.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>