CTH [The Human Chemical-Genetic Interaction Map Project]

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======= CTH =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CTH
  * **<color #00a2e8>Official Name</color>**: cystathionine gamma-lyase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1491|1491]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P32929|P32929]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CTH&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CTH|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607657|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function. {ECO:0000269|PubMed:19019829, ECO:0000269|PubMed:19261609, ECO:0000269|PubMed:22169477}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cys Met Meta PP|
|Aminotran 5|
|Aminotran 1 2|
|DegT DnrJ EryC1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine|
|L-cysteine desulfhydrase activity|
|positive regulation of aortic smooth muscle cell differentiation|
|L-cystine L-cysteine-lyase (deaminating)|
|regulation of aortic smooth muscle cell differentiation|
|cystathionine gamma-lyase activity|
|protein sulfhydration|
|protein-pyridoxal-5-phosphate linkage|
|cysteine biosynthetic process via cystathionine|
|cysteine biosynthetic process|
|hydrogen sulfide biosynthetic process|
|homoserine metabolic process|
|transsulfuration|
|carbon-sulfur lyase activity|
|toxin biosynthetic process|
|hydrogen sulfide metabolic process|
|positive regulation of vascular smooth muscle cell differentiation|
|protein-cofactor linkage|
|cysteine metabolic process|
|homocysteine metabolic process|
|positive regulation of smooth muscle cell differentiation|
|regulation of vascular smooth muscle cell differentiation|
|sulfur amino acid catabolic process|
|serine family amino acid biosynthetic process|
|sulfur amino acid biosynthetic process|
|secondary metabolite biosynthetic process|
|toxin metabolic process|
|regulation of smooth muscle cell differentiation|
|sulfur amino acid metabolic process|
|serine family amino acid metabolic process|
|pyridoxal phosphate binding|
|sulfur compound catabolic process|
|secondary metabolic process|
|alpha-amino acid biosynthetic process|
|cellular amino acid biosynthetic process|
|positive regulation of muscle cell differentiation|
|protein homotetramerization|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|endoplasmic reticulum unfolded protein response|
|cellular amino acid catabolic process|
|cellular response to unfolded protein|
|cellular response to topologically incorrect protein|
|protein tetramerization|
|positive regulation of NF-kappaB transcription factor activity|
|regulation of muscle cell differentiation|
|response to unfolded protein|
|sulfur compound biosynthetic process|
|positive regulation of vasculature development|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|response to topologically incorrect protein|
|calmodulin binding|
|alpha-amino acid metabolic process|
|negative regulation of apoptotic signaling pathway|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|response to endoplasmic reticulum stress|
|positive regulation of DNA-binding transcription factor activity|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|cellular amino acid metabolic process|
|peptidyl-lysine modification|
|regulation of vasculature development|
|protein homooligomerization|
|sulfur compound metabolic process|
|regulation of apoptotic signaling pathway|
|regulation of DNA-binding transcription factor activity|
|small molecule catabolic process|
|drug metabolic process|
|protein complex oligomerization|
|small molecule biosynthetic process|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|carboxylic acid metabolic process|
|positive regulation of cell differentiation|
|negative regulation of cell death|
|oxoacid metabolic process|
|cellular response to cytokine stimulus|
|positive regulation of intracellular signal transduction|
|organic acid metabolic process|
|organonitrogen compound catabolic process|
|identical protein binding|
|response to cytokine|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|organonitrogen compound biosynthetic process|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10140
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CTH Expression in NALM6 Cells: 3.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>