CTNND1 [The Human Chemical-Genetic Interaction Map Project]

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======= CTNND1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CTNND1
  * **<color #00a2e8>Official Name</color>**: catenin delta 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1500|1500]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60716|O60716]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CTNND1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CTNND1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601045|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Arm|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|zonula adherens|
|entry of bacterium into host cell|
|presynaptic active zone cytoplasmic component|
|postsynaptic density, intracellular component|
|catenin complex|
|hippocampal mossy fiber to CA3 synapse|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|Schaffer collateral - CA1 synapse|
|adherens junction organization|
|entry into host cell|
|entry into host|
|cell-cell junction assembly|
|cell-cell adherens junction|
|growth cone|
|cell-cell junction organization|
|dendritic spine|
|interaction with host|
|midbody|
|cell junction assembly|
|cell-cell junction|
|negative regulation of canonical Wnt signaling pathway|
|lamellipodium|
|negative regulation of Wnt signaling pathway|
|cell junction organization|
|regulation of canonical Wnt signaling pathway|
|cadherin binding|
|signaling receptor binding|
|glutamatergic synapse|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|regulation of Wnt signaling pathway|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|protein kinase binding|
|cell-cell adhesion|
|brain development|
|head development|
|symbiotic process|
|interspecies interaction between organisms|
|cell adhesion|
|biological adhesion|
|central nervous system development|
|cell-cell signaling|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of response to stimulus|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.74|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|1.76|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9846
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CTNND1 Expression in NALM6 Cells: 3.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>