CTSC [The Human Chemical-Genetic Interaction Map Project]

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======= CTSC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CTSC
  * **<color #00a2e8>Official Name</color>**: cathepsin C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1075|1075]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P53634|P53634]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CTSC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CTSC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602365|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. [provided by RefSeq, Nov 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CathepsinC exc|
|Peptidase C1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peptidase activator activity involved in apoptotic process|
|positive regulation of microglial cell activation|
|negative regulation of myelination|
|chloride ion binding|
|positive regulation of neuroinflammatory response|
|regulation of microglial cell activation|
|T cell mediated cytotoxicity|
|positive regulation of macrophage activation|
|negative regulation of nervous system process|
|cysteine-type peptidase activity|
|regulation of neuroinflammatory response|
|leukocyte mediated cytotoxicity|
|T cell mediated immunity|
|COPII-coated ER to Golgi transport vesicle|
|regulation of myelination|
|phosphatase binding|
|regulation of macrophage activation|
|protein self-association|
|COPII vesicle coating|
|vesicle targeting, rough ER to cis-Golgi|
|vesicle coating|
|COPII-coated vesicle budding|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|vesicle targeting, to, from or within Golgi|
|Golgi vesicle budding|
|cell killing|
|vesicle targeting|
|azurophil granule lumen|
|cysteine-type endopeptidase activity|
|vesicle budding from membrane|
|chaperone binding|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of nervous system process|
|positive regulation of inflammatory response|
|positive regulation of cellular protein catabolic process|
|serine-type endopeptidase activity|
|positive regulation of apoptotic signaling pathway|
|establishment of vesicle localization|
|vesicle localization|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|regulation of cellular protein catabolic process|
|lysosome|
|lymphocyte mediated immunity|
|aging|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|vesicle organization|
|endoplasmic reticulum lumen|
|negative regulation of nervous system development|
|regulation of inflammatory response|
|positive regulation of proteolysis|
|establishment of organelle localization|
|collagen-containing extracellular matrix|
|positive regulation of cellular catabolic process|
|Golgi vesicle transport|
|regulation of protein catabolic process|
|regulation of apoptotic signaling pathway|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|positive regulation of catabolic process|
|positive regulation of defense response|
|neutrophil degranulation|
|centrosome|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|organelle localization|
|myeloid leukocyte activation|
|proteolysis involved in cellular protein catabolic process|
|regulation of system process|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|adaptive immune response|
|cellular protein catabolic process|
|Golgi membrane|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|protein catabolic process|
|intracellular membrane-bounded organelle|
|positive regulation of cell death|
|regulated exocytosis|
|regulation of proteolysis|
|regulation of defense response|
|leukocyte mediated immunity|
|exocytosis|
|regulation of cellular catabolic process|
|membrane organization|
|cellular macromolecule catabolic process|
|apoptotic process|
|regulation of nervous system development|
|leukocyte activation|
|negative regulation of developmental process|
|regulation of catabolic process|
|secretion by cell|
|export from cell|
|macromolecule catabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|identical protein binding|
|cell activation|
|immune effector process|
|cell death|
|regulation of response to external stimulus|
|secretion|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|proteolysis|
|regulation of response to stress|
|intracellular transport|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|2.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10435
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CTSC Expression in NALM6 Cells: 7.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>