CTSV [The Human Chemical-Genetic Interaction Map Project]

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======= CTSV =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CTSV
  * **<color #00a2e8>Official Name</color>**: cathepsin V
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1515|1515]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60911|O60911]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CTSV&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CTSV|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603308|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cysteine protease. May have an important role in corneal physiology. {ECO:0000269|PubMed:10029531, ECO:0000269|PubMed:9727401}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Inhibitor I29|
|Peptidase C1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|kininogen binding|
|response to odorant|
|autophagic cell death|
|Sertoli cell differentiation|
|decidualization|
|response to gonadotropin|
|aminopeptidase activity|
|cysteine-type peptidase activity|
|maternal placenta development|
|multicellular organism aging|
|regulation of keratinocyte differentiation|
|peptide binding|
|regulation of epidermal cell differentiation|
|microvillus|
|maternal process involved in female pregnancy|
|extracellular matrix disassembly|
|apical part of cell|
|nerve development|
|regulation of epidermis development|
|secretory granule|
|cysteine-type endopeptidase activity|
|lysosomal lumen|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|male gonad development|
|perikaryon|
|development of primary male sexual characteristics|
|response to glucose|
|regulation of epithelial cell differentiation|
|response to hexose|
|response to glucocorticoid|
|response to monosaccharide|
|cellular response to starvation|
|placenta development|
|male sex differentiation|
|response to corticosteroid|
|response to carbohydrate|
|antigen processing and presentation of exogenous peptide antigen|
|female pregnancy|
|antigen processing and presentation of exogenous antigen|
|antigen processing and presentation of peptide antigen|
|response to starvation|
|gonad development|
|multi-multicellular organism process|
|antigen processing and presentation|
|development of primary sexual characteristics|
|cellular response to nutrient levels|
|lysosome|
|cellular response to extracellular stimulus|
|sex differentiation|
|protein-containing complex binding|
|aging|
|neuron projection|
|response to steroid hormone|
|cellular response to external stimulus|
|extracellular matrix organization|
|extracellular structure organization|
|external side of plasma membrane|
|cellular component disassembly|
|reproductive structure development|
|reproductive system development|
|response to nutrient levels|
|response to extracellular stimulus|
|spermatogenesis|
|male gamete generation|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|developmental process involved in reproduction|
|epithelial cell differentiation|
|protein catabolic process|
|gamete generation|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|response to lipid|
|cellular macromolecule catabolic process|
|response to hormone|
|response to organic cyclic compound|
|multi-organism reproductive process|
|macromolecule catabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|cell death|
|epithelium development|
|proteolysis|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|extracellular space|
|cellular response to stress|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-2.63|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-2.18|
|[[:results:exp358|FK-506 5μM R07 exp358]]|-2.03|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|1.7|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.86|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|2.15|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|2.51|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10308
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CTSV Expression in NALM6 Cells: 3.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>