CTU2 [The Human Chemical-Genetic Interaction Map Project]

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======= CTU2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CTU2
  * **<color #00a2e8>Official Name</color>**: cytosolic thiouridylase subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=348180|348180]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q2VPK5|Q2VPK5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CTU2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CTU2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617057|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. {ECO:0000255|HAMAP-Rule:MF_03054, ECO:0000269|PubMed:19017811}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF2392|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sulfurtransferase activity|
|protein urmylation|
|tRNA wobble position uridine thiolation|
|tRNA thio-modification|
|nucleotidyltransferase activity|
|tRNA wobble uridine modification|
|tRNA wobble base modification|
|tRNA binding|
|tRNA modification|
|tRNA processing|
|RNA modification|
|tRNA metabolic process|
|ncRNA processing|
|ncRNA metabolic process|
|protein-containing complex|
|protein modification by small protein conjugation|
|RNA processing|
|protein modification by small protein conjugation or removal|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.34|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-2.09|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.8|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-1.77|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-1.76|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.74|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.76|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.78|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.78|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.81|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.82|
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.86|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|1.94|
|[[:results:exp274|Citral 50μM R06 exp274]]|2|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|2.1|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.11|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.14|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.18|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.18|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.35|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.37|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.37|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.81|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.91|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.93|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|3.52|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:ctu1|CTU1]]|0.705|
|[[:human genes:u:urm1|URM1]]|0.669|
|[[:human genes:e:elp3|ELP3]]|0.667|
|[[:human genes:k:kti12|KTI12]]|0.65|
|[[:human genes:e:elp6|ELP6]]|0.647|
|[[:human genes:m:mocs3|MOCS3]]|0.628|
|[[:human genes:d:dph3|DPH3]]|0.623|
|[[:human genes:e:elp2|ELP2]]|0.608|
|[[:human genes:i:ikbkap|IKBKAP]]|0.59|
|[[:human genes:e:elp5|ELP5]]|0.523|
|[[:human genes:n:nr2c2ap|NR2C2AP]]|0.516|
|[[:human genes:a:alkbh8|ALKBH8]]|0.495|
|[[:human genes:e:elp4|ELP4]]|0.453|
|[[:human genes:s:slc7a1|SLC7A1]]|0.453|
|[[:human genes:c:c7orf26|C7orf26]]|0.452|
|[[:human genes:d:dph1|DPH1]]|0.437|
|[[:human genes:y:ythdf2|YTHDF2]]|0.413|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 303/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|14/28|
|blood|8/28|
|bone|9/26|
|breast|9/33|
|central nervous system|24/56|
|cervix|0/4|
|colorectal|8/17|
|esophagus|5/13|
|fibroblast|1/1|
|gastric|5/16|
|kidney|8/21|
|liver|14/20|
|lung|29/75|
|lymphocyte|3/16|
|ovary|13/26|
|pancreas|12/24|
|peripheral nervous system|2/16|
|plasma cell|5/15|
|prostate|0/1|
|skin|12/24|
|soft tissue|4/9|
|thyroid|0/2|
|upper aerodigestive|10/22|
|urinary tract|18/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1117
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CTU2 Expression in NALM6 Cells: 4.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>