CXADR [The Human Chemical-Genetic Interaction Map Project]

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======= CXADR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CXADR
  * **<color #00a2e8>Official Name</color>**: CXADR Ig-like cell adhesion molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1525|1525]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78310|P78310]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CXADR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CXADR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602621|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. [provided by RefSeq, May 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|V-set|
|I-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell adhesive protein binding involved in AV node cell-bundle of His cell communication|
|AV node cell-bundle of His cell adhesion involved in cell communication|
|regulation of AV node cell action potential|
|connexin binding|
|gamma-delta T cell activation|
|cardiac muscle cell-cardiac muscle cell adhesion|
|germ cell migration|
|AV node cell to bundle of His cell communication|
|cardiac muscle fiber development|
|apicolateral plasma membrane|
|transepithelial transport|
|epithelial structure maintenance|
|regulation of cardiac muscle cell action potential|
|heterotypic cell-cell adhesion|
|cell communication involved in cardiac conduction|
|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|
|regulation of action potential|
|muscle fiber development|
|cell adhesion molecule binding|
|homotypic cell-cell adhesion|
|cardiac muscle cell development|
|adherens junction|
|cardiac cell development|
|actin cytoskeleton reorganization|
|regulation of cardiac conduction|
|filopodium|
|cell body|
|virus receptor activity|
|neutrophil chemotaxis|
|beta-catenin binding|
|acrosomal vesicle|
|PDZ domain binding|
|cardiac muscle cell differentiation|
|granulocyte chemotaxis|
|neutrophil migration|
|cardiac conduction|
|viral entry into host cell|
|granulocyte migration|
|entry into host|
|entry into host cell|
|cell-cell adherens junction|
|cardiocyte differentiation|
|bicellular tight junction|
|myeloid leukocyte migration|
|growth cone|
|integrin binding|
|striated muscle cell development|
|multicellular organismal signaling|
|cell-cell junction organization|
|leukocyte chemotaxis|
|muscle cell development|
|interaction with host|
|cardiac muscle tissue development|
|cell-cell junction|
|tissue homeostasis|
|basolateral plasma membrane|
|striated muscle cell differentiation|
|viral life cycle|
|cell chemotaxis|
|cell junction organization|
|membrane raft|
|T cell activation|
|regulation of heart contraction|
|muscle cell differentiation|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|striated muscle tissue development|
|regulation of blood circulation|
|muscle tissue development|
|neuron projection|
|multicellular organismal homeostasis|
|anatomical structure homeostasis|
|cellular process involved in reproduction in multicellular organism|
|leukocyte migration|
|lymphocyte activation|
|regulation of membrane potential|
|mitochondrion organization|
|muscle structure development|
|actin cytoskeleton organization|
|cell-cell adhesion|
|heart development|
|cell junction|
|chemotaxis|
|taxis|
|actin filament-based process|
|regulation of system process|
|protein-containing complex|
|gamete generation|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|circulatory system development|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|cell migration|
|multi-organism reproductive process|
|cell activation|
|cell motility|
|localization of cell|
|cytoskeleton organization|
|regulation of immune response|
|locomotion|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|movement of cell or subcellular component|
|homeostatic process|
|cell development|
|regulation of immune system process|
|tissue development|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13036
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CXADR Expression in NALM6 Cells: 1.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>