CXCL10 [The Human Chemical-Genetic Interaction Map Project]

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======= CXCL10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CXCL10
  * **<color #00a2e8>Official Name</color>**: C-X-C motif chemokine ligand 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3627|3627]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P02778|P02778]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CXCL10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CXCL10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147310|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of myoblast fusion|
|negative regulation of syncytium formation by plasma membrane fusion|
|CXCR3 chemokine receptor binding|
|regulation of endothelial tube morphogenesis|
|cAMP-dependent protein kinase regulator activity|
|endothelial cell activation|
|T cell chemotaxis|
|regulation of T cell chemotaxis|
|positive regulation of monocyte chemotaxis|
|negative regulation of myotube differentiation|
|regulation of myoblast fusion|
|positive regulation of mononuclear cell migration|
|negative regulation of myoblast differentiation|
|regulation of monocyte chemotaxis|
|regulation of lymphocyte chemotaxis|
|response to auditory stimulus|
|T cell migration|
|regulation of syncytium formation by plasma membrane fusion|
|response to vitamin D|
|positive regulation of T cell migration|
|chemoattractant activity|
|positive regulation of lymphocyte migration|
|negative regulation of striated muscle cell differentiation|
|positive regulation of release of sequestered calcium ion into cytosol|
|regulation of T cell migration|
|regulation of mononuclear cell migration|
|lymphocyte chemotaxis|
|positive chemotaxis|
|chemokine activity|
|response to cold|
|regulation of myoblast differentiation|
|positive regulation of calcium ion transport into cytosol|
|negative regulation of muscle cell differentiation|
|response to gamma radiation|
|regulation of myotube differentiation|
|regulation of lymphocyte migration|
|antimicrobial humoral immune response mediated by antimicrobial peptide|
|lymphocyte migration|
|positive regulation of calcium ion transmembrane transport|
|cellular response to heat|
|regulation of release of sequestered calcium ion into cytosol|
|chemokine-mediated signaling pathway|
|neutrophil chemotaxis|
|response to vitamin|
|positive regulation of leukocyte chemotaxis|
|granulocyte chemotaxis|
|cellular response to chemokine|
|response to chemokine|
|neutrophil migration|
|regulation of calcium ion transport into cytosol|
|granulocyte migration|
|regulation of striated muscle cell differentiation|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|response to heat|
|antimicrobial humoral response|
|regulation of leukocyte chemotaxis|
|negative regulation of vasculature development|
|positive regulation of calcium ion transport|
|regulation of sequestering of calcium ion|
|myeloid leukocyte migration|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|positive regulation of leukocyte migration|
|positive regulation of chemotaxis|
|positive regulation of cation transmembrane transport|
|leukocyte chemotaxis|
|regulation of calcium ion transmembrane transport|
|cAMP-mediated signaling|
|response to ionizing radiation|
|regulation of muscle cell differentiation|
|positive regulation of ion transmembrane transport|
|heparin binding|
|cyclic-nucleotide-mediated signaling|
|response to temperature stimulus|
|regulation of morphogenesis of an epithelium|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|defense response to virus|
|regulation of leukocyte migration|
|positive regulation of transmembrane transport|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|cell chemotaxis|
|regulation of chemotaxis|
|response to mechanical stimulus|
|response to nutrient|
|cellular response to biotic stimulus|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|regulation of calcium ion transport|
|positive regulation of ion transport|
|response to virus|
|positive regulation of cytosolic calcium ion concentration|
|regulation of angiogenesis|
|muscle organ development|
|response to lipopolysaccharide|
|regulation of vasculature development|
|response to molecule of bacterial origin|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|signaling receptor binding|
|second-messenger-mediated signaling|
|humoral immune response|
|leukocyte migration|
|regulation of metal ion transport|
|blood circulation|
|external side of plasma membrane|
|circulatory system process|
|cellular calcium ion homeostasis|
|response to radiation|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|muscle structure development|
|regulation of ion transmembrane transport|
|divalent inorganic cation homeostasis|
|inflammatory response|
|response to nutrient levels|
|positive regulation of cell migration|
|cellular response to lipid|
|positive regulation of cell motility|
|response to extracellular stimulus|
|positive regulation of cellular component movement|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|positive regulation of response to external stimulus|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cytokine-mediated signaling pathway|
|response to bacterium|
|regulation of ion transport|
|negative regulation of cellular component organization|
|cation homeostasis|
|negative regulation of cell differentiation|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|regulation of protein kinase activity|
|regulation of cell migration|
|response to lipid|
|regulation of kinase activity|
|cellular homeostasis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|response to organic cyclic compound|
|negative regulation of developmental process|
|defense response to other organism|
|cell migration|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|cell activation|
|localization of cell|
|cell motility|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|chemical homeostasis|
|cell-cell signaling|
|positive regulation of immune system process|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|regulation of protein phosphorylation|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|2.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15600
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CXCL10 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>