CXCR4 [The Human Chemical-Genetic Interaction Map Project]

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======= CXCR4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CXCR4
  * **<color #00a2e8>Official Name</color>**: C-X-C motif chemokine receptor 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7852|7852]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61073|P61073]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CXCR4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CXCR4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/162643|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. {ECO:0000269|PubMed:10074102, ECO:0000269|PubMed:10644702, ECO:0000269|PubMed:10825158, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:17197449, ECO:0000269|PubMed:20048153, ECO:0000269|PubMed:20228059, ECO:0000269|PubMed:20505072, ECO:0000269|PubMed:8752280, ECO:0000269|PubMed:8752281}. (Microbial infection) Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. {ECO:0000269|PubMed:11276205}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srsx|
|CXCR4 N|
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|C-X-C motif chemokine 12 receptor activity|
|CXCL12-activated CXCR4 signaling pathway|
|C-X-C chemokine receptor CXCR4 signaling pathway|
|positive regulation of macrophage migration inhibitory factor signaling pathway|
|response to ultrasound|
|positive regulation of mesenchymal stem cell migration|
|regulation of mesenchymal stem cell migration|
|regulation of macrophage migration inhibitory factor signaling pathway|
|chemokine (C-X-C motif) ligand 12 signaling pathway|
|positive regulation of vascular wound healing|
|regulation of vascular wound healing|
|myosin light chain binding|
|C-X-C chemokine receptor activity|
|multi-organism membrane fusion|
|membrane fusion involved in viral entry into host cell|
|fusion of virus membrane with host plasma membrane|
|multi-organism membrane organization|
|endothelial tube morphogenesis|
|morphogenesis of an endothelium|
|detection of mechanical stimulus involved in sensory perception of pain|
|myelin maintenance|
|detection of temperature stimulus involved in sensory perception|
|detection of temperature stimulus involved in sensory perception of pain|
|dendritic cell chemotaxis|
|detection of temperature stimulus|
|sensory perception of temperature stimulus|
|dendritic cell migration|
|multi-organism cellular process|
|positive regulation of dendrite extension|
|C-C chemokine receptor activity|
|positive regulation of oligodendrocyte differentiation|
|chemokine binding|
|C-C chemokine binding|
|regulation of dendrite extension|
|detection of mechanical stimulus involved in sensory perception|
|response to morphine|
|response to isoquinoline alkaloid|
|coreceptor activity|
|regulation of oligodendrocyte differentiation|
|cell leading edge|
|positive regulation of glial cell differentiation|
|detection of mechanical stimulus|
|neuron recognition|
|positive regulation of cytokine-mediated signaling pathway|
|positive regulation of wound healing|
|drug binding|
|positive regulation of response to cytokine stimulus|
|telencephalon cell migration|
|forebrain cell migration|
|positive regulation of response to wounding|
|response to activity|
|positive regulation of gliogenesis|
|regulation of glial cell differentiation|
|sensory perception of pain|
|virus receptor activity|
|response to anesthetic|
|cardiac muscle contraction|
|chemokine-mediated signaling pathway|
|ubiquitin binding|
|endothelial cell differentiation|
|heart contraction|
|response to chemokine|
|cellular response to chemokine|
|plasma membrane organization|
|viral entry into host cell|
|endothelium development|
|positive regulation of cold-induced thermogenesis|
|heart process|
|entry into host|
|entry into host cell|
|myelination|
|axon ensheathment|
|ensheathment of neurons|
|striated muscle contraction|
|response to alkaloid|
|regulation of gliogenesis|
|neuron migration|
|detection of external stimulus|
|detection of abiotic stimulus|
|late endosome|
|membrane fusion|
|positive regulation of chemotaxis|
|regulation of wound healing|
|regulation of cold-induced thermogenesis|
|leukocyte chemotaxis|
|calcium-mediated signaling|
|activation of MAPK activity|
|interaction with host|
|positive regulation of angiogenesis|
|regulation of cytokine-mediated signaling pathway|
|positive regulation of cell growth|
|sensory perception of mechanical stimulus|
|regulation of response to wounding|
|positive regulation of developmental growth|
|regulation of response to cytokine stimulus|
|response to temperature stimulus|
|positive regulation of vasculature development|
|response to ammonium ion|
|epithelial cell development|
|viral life cycle|
|regulation of viral process|
|cell chemotaxis|
|regulation of chemotaxis|
|response to mechanical stimulus|
|regulation of symbiosis, encompassing mutualism through parasitism|
|cell recognition|
|regulation of calcium ion transport|
|muscle contraction|
|lysosome|
|cytoplasmic vesicle|
|early endosome|
|telencephalon development|
|positive regulation of growth|
|axon guidance|
|positive regulation of MAP kinase activity|
|neuron projection guidance|
|actin binding|
|positive regulation of neuron projection development|
|response to virus|
|positive regulation of cytosolic calcium ion concentration|
|regulation of angiogenesis|
|ubiquitin protein ligase binding|
|muscle system process|
|response to xenobiotic stimulus|
|epithelial tube morphogenesis|
|regulation of vasculature development|
|regulation of cytosolic calcium ion concentration|
|activation of protein kinase activity|
|regulation of developmental growth|
|second-messenger-mediated signaling|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|response to hypoxia|
|response to decreased oxygen levels|
|positive regulation of neuron differentiation|
|axonogenesis|
|leukocyte migration|
|response to oxygen levels|
|positive regulation of cell projection organization|
|regulation of metal ion transport|
|forebrain development|
|blood circulation|
|external side of plasma membrane|
|circulatory system process|
|cellular response to drug|
|axon development|
|regulation of cell growth|
|endomembrane system organization|
|morphogenesis of an epithelium|
|cell morphogenesis involved in neuron differentiation|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|divalent inorganic cation homeostasis|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|inflammatory response|
|positive regulation of cell migration|
|cell part morphogenesis|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cell motility|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|detection of stimulus involved in sensory perception|
|cell junction|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|cell morphogenesis involved in differentiation|
|cellular metal ion homeostasis|
|tissue morphogenesis|
|positive regulation of kinase activity|
|protein-containing complex|
|positive regulation of response to external stimulus|
|cell surface|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|tube morphogenesis|
|positive regulation of transferase activity|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of growth|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|epithelial cell differentiation|
|detection of stimulus|
|regulation of plasma membrane bounded cell projection organization|
|regulation of ion transport|
|viral process|
|cation homeostasis|
|regulation of cell projection organization|
|inorganic ion homeostasis|
|cell morphogenesis|
|G protein-coupled receptor activity|
|brain development|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|regulation of multi-organism process|
|head development|
|symbiotic process|
|ion homeostasis|
|regulation of protein kinase activity|
|neuron development|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|tube development|
|regulation of cell migration|
|membrane organization|
|regulation of kinase activity|
|cellular homeostasis|
|regulation of cell motility|
|response to organic cyclic compound|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|cell migration|
|positive regulation of cell differentiation|
|sensory perception|
|regulation of transferase activity|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|programmed cell death|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|chemical homeostasis|
|epithelium development|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cell projection organization|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|nervous system process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-3.25|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-2.87|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.62|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-2.42|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.95|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-1.77|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15335
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CXCR4 Expression in NALM6 Cells: 9.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>