CXXC1 [The Human Chemical-Genetic Interaction Map Project]

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======= CXXC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CXXC1
  * **<color #00a2e8>Official Name</color>**: CXXC finger protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=30827|30827]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P0U4|Q9P0U4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CXXC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CXXC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609150|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. {ECO:0000269|PubMed:21407193}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-CpG bind C|
|PHD|
|zf-CXXC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|unmethylated CpG binding|
|Set1C/COMPASS complex|
|histone methyltransferase activity (H3-K4 specific)|
|proximal promoter sequence-specific DNA binding|
|histone H3-K4 methylation|
|histone methyltransferase complex|
|IRE1-mediated unfolded protein response|
|histone lysine methylation|
|peptidyl-lysine methylation|
|histone methylation|
|endoplasmic reticulum unfolded protein response|
|nuclear matrix|
|cellular response to unfolded protein|
|protein methylation|
|protein alkylation|
|cellular response to topologically incorrect protein|
|response to unfolded protein|
|response to topologically incorrect protein|
|macromolecule methylation|
|response to endoplasmic reticulum stress|
|methylation|
|peptidyl-lysine modification|
|histone modification|
|covalent chromatin modification|
|nuclear speck|
|chromatin organization|
|zinc ion binding|
|peptidyl-amino acid modification|
|chromosome organization|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-2.4|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-2.14|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.95|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-1.72|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.81|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|1.92|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.421|
|[[:human genes:p:polr2j3|POLR2J3]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 14/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|0/14|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1029
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CXXC1 Expression in NALM6 Cells: 6.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>