CYB5R4 [The Human Chemical-Genetic Interaction Map Project]

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======= CYB5R4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CYB5R4
  * **<color #00a2e8>Official Name</color>**: cytochrome b5 reductase 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51167|51167]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7L1T6|Q7L1T6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CYB5R4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CYB5R4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608343|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CS|
|Cyt-b5|
|FAD binding 6|
|NAD binding 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor|
|detection of oxygen|
|cytochrome-b5 reductase activity, acting on NAD(P)H|
|NAD(P)H oxidase activity|
|insulin secretion|
|superoxide metabolic process|
|bicarbonate transport|
|peptide hormone secretion|
|hormone secretion|
|hormone transport|
|reactive oxygen species metabolic process|
|heme binding|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|signal release|
|peptide secretion|
|glucose homeostasis|
|carbohydrate homeostasis|
|response to antibiotic|
|response to oxygen levels|
|generation of precursor metabolites and energy|
|organic anion transport|
|detection of chemical stimulus|
|regulation of hormone levels|
|anion transport|
|detection of stimulus|
|perinuclear region of cytoplasm|
|endoplasmic reticulum membrane|
|oxidation-reduction process|
|secretion by cell|
|endoplasmic reticulum|
|export from cell|
|chemical homeostasis|
|cell-cell signaling|
|secretion|
|response to abiotic stimulus|
|ion transport|
|protein transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|homeostatic process|
|cell development|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-2.48|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-1.85|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.78|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.83|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.05|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.59|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.83|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|3.49|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|3.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:ppp2r4|PPP2R4]]|0.584|
|[[:human genes:t:tiprl|TIPRL]]|0.474|
|[[:human genes:p:ppp6c|PPP6C]]|0.464|
|[[:human genes:l:lcmt1|LCMT1]]|0.433|
|[[:human genes:p:ppp6r3|PPP6R3]]|0.419|
|[[:human genes:p:ppme1|PPME1]]|0.414|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 19/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|3/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|4/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|2/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4753
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CYB5R4 Expression in NALM6 Cells: 5.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>